Initial validation and results of the Symptoms in Persons At Risk of Rheumatoid Arthritis (SPARRA) questionnaire: a EULAR project

Van Beers-Tas, M.H., Ter Wee, M.M., Van Tuyl, L.H., Maat, B., Hoogland, W., Hensvold, A.H., Catrina, A.I., Mosor, E., Stamm, T.A., Finckh, A., Courvoisier, D.S., Filer, A., Sahbudin, I., Stack, R.J. ORCID: 0000-0002-0516-0228, Raza, K. and Van Schaardenburg, D., 2018. Initial validation and results of the Symptoms in Persons At Risk of Rheumatoid Arthritis (SPARRA) questionnaire: a EULAR project. RMD Open, 4 (1): e000641. ISSN 2056-5933

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Abstract

Objectives: To describe the development and assess the psychometric properties of the novel 'Symptoms in Persons At Risk of Rheumatoid Arthritis' (SPARRA) questionnaire in individuals at risk of rheumatoid arthritis (RA) and to quantify their symptoms.

Methods: The questionnaire items were derived from a qualitative study in patients with seropositive arthralgia. The questionnaire was administered to 219 individuals at risk of RA on the basis of symptoms or autoantibody positivity: 74% rheumatoid factor and/or anticitrullinated protein antibodies positive, 26% seronegative. Validity, reliability and responsiveness were assessed. Eighteen first degree relatives (FDR) of patients with RA were used for comparison.

Results: Face and content validity were high. The test-retest showed good agreement and reliability (1 week and 6 months). Overall, construct validity was low to moderate, with higher values for concurrent validity, suggesting that some questions reflect symptom content not captured with regular Visual Analogue Scale pain/well-being. Responsiveness was low (small subgroup). Finally, the burden of symptoms in both seronegative and seropositive at risk individuals was high, with pain, stiffness and fatigue being the most common ones with a major impact on daily functioning. The FDR cohort (mostly healthy individuals) showed a lower burden of symptoms; however, the distribution of symptoms was similar.

Conclusions: The SPARRA questionnaire has good psychometric properties and can add information to currently available clinical measures in individuals at risk of RA. The studied group had a high burden and impact of symptoms. Future studies should evaluate whether SPARRA data can improve the prediction of RA in at risk individuals.

Item Type: Journal article
Publication Title: RMD Open
Creators: Van Beers-Tas, M.H., Ter Wee, M.M., Van Tuyl, L.H., Maat, B., Hoogland, W., Hensvold, A.H., Catrina, A.I., Mosor, E., Stamm, T.A., Finckh, A., Courvoisier, D.S., Filer, A., Sahbudin, I., Stack, R.J., Raza, K. and Van Schaardenburg, D.
Publisher: BMJ Publishing Group
Date: 21 May 2018
Volume: 4
Number: 1
ISSN: 2056-5933
Identifiers:
NumberType
10.1136/rmdopen-2017-000641DOI
Rights: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Divisions: Schools > School of Social Sciences
Depositing User: Linda Sullivan
Date Added: 28 Jun 2018 10:56
Last Modified: 28 Jun 2018 10:56
URI: http://irep.ntu.ac.uk/id/eprint/33938

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