Tools
Tools
Matlung, H.L., Babes, L., Zhao, X.W., Van Houdt, M., Treffers, L.W., Van Rees, D.J., Franke, K., Schornagel, K., Verkuijlen, P., Janssen, H., Halonen, P., Lieftink, C., Beijersbergen, R.L., Leusen, J.H.W., Boelens, J.J., Kuhnle, I., Van der Werff Ten Bosch, J., Seeger, K., Rutella, S. 
ORCID: 0000-0003-1970-7375, Pagliara, D., Matozaki, T., Suzuki, E., Menke-van der Houven van Oordt, C.W., Van Bruggen, R., Roos, D., Van Lier, R.A.W., Kuijpers, T.W., Kubes, P. and Van den Berg, T.K.,
2018.
Neutrophils kill antibody-opsonized cancer cells by trogoptosis.
Cell Reports, 23 (13), pp. 3946-3959.
ISSN 2211-1247
|
Text
11448_a999_Rutella.pdf - Published version Download (5MB) | Preview |
Abstract
Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through antibody-dependent cellular cytotoxicity (ADCC), and this can be mediated by various Fc-receptor-expressing immune cells, including neutrophils. However, the mechanism(s) by which neutrophils kill antibody-opsonized cancer cells has not been established. Here, we demonstrate that neutrophils can exert a mode of destruction of cancer cells, which involves antibody-mediated trogocytosis by neutrophils. Intimately associated with this is an active mechanical disruption of the cancer cell plasma membrane, leading to a lytic (i.e., necrotic) type of cancer cell death. Furthermore, this mode of destruction of antibody-opsonized cancer cells by neutrophils is potentiated by CD47-SIRPa checkpoint blockade. Collectively, these findings show that neutrophil ADCC toward cancer cells occurs by a mechanism of cytotoxicity called trogoptosis, which can be further improved by targeting CD47-SIRPa interactions.
| Item Type: | Journal article | ||||
|---|---|---|---|---|---|
| Publication Title: | Cell Reports | ||||
| Creators: | Matlung, H.L., Babes, L., Zhao, X.W., Van Houdt, M., Treffers, L.W., Van Rees, D.J., Franke, K., Schornagel, K., Verkuijlen, P., Janssen, H., Halonen, P., Lieftink, C., Beijersbergen, R.L., Leusen, J.H.W., Boelens, J.J., Kuhnle, I., Van der Werff Ten Bosch, J., Seeger, K., Rutella, S., Pagliara, D., Matozaki, T., Suzuki, E., Menke-van der Houven van Oordt, C.W., Van Bruggen, R., Roos, D., Van Lier, R.A.W., Kuijpers, T.W., Kubes, P. and Van den Berg, T.K. | ||||
| Publisher: | Elsevier | ||||
| Date: | 26 June 2018 | ||||
| Volume: | 23 | ||||
| Number: | 13 | ||||
| ISSN: | 2211-1247 | ||||
| Identifiers: |
|
||||
| Divisions: | Schools > School of Science and Technology | ||||
| Record created by: | Linda Sullivan | ||||
| Date Added: | 28 Jun 2018 13:37 | ||||
| Last Modified: | 02 Aug 2018 14:09 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/33943 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
