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Alex J. McCarthy, David Negus, Patricia Martin, Catarina Pechincha, Eric Oswald, Richard A. Stabler, Peter W. Taylor
Pathoadaptive Mutations of Escherichia coli K1 in Experimental Neonatal Systemic Infection
www.plosone.org
www.plosone.org
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3.3449 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
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(K1)Tj
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(15)Tj
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0.9921 0 Td
[()7( )10(\n)12()]TJ
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(two)Tj
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(17)Tj
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(18)Tj
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[()]TJ
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0.9921 0 Td
[()7( )10(\n)12()]TJ
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1.559 0 Td
(A192PP)Tj
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1.7291 0 Td
(the)Tj
1.4684 0 Td
(intermediate)Tj
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2.7609 0 Td
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 317.1968 cm
BT
/F3 1 Tf
1 TL
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4.5071 0 Td
(and)Tj
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(strains)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
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[()]TJ
/F9 1 Tf
(.)Tj
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[()7( )10(\n)12()]TJ
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1.559 0 Td
(A192)Tj
2.3301 0 Td
(\(O18:K1\))Tj
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(1977)Tj
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(septicemia)Tj
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[()]TJ
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0.9921 0 Td
[()7( )10(\n)12()]TJ
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(A192PP)Tj
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(a)Tj
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(colony)Tj
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(isolated)Tj
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(of)Tj
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(an)Tj
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(animal)Tj
2.9706 0 Td
(colonized)Tj
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(by)Tj
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1.1792 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
0.9978 0 Td
[()7( )10(\n)12()]TJ
/F9 1 Tf
1.559 0 Td
(A192)Tj
2.3301 0 Td
(was)Tj
1.7008 0 Td
(designated)Tj
4.4957 0 Td
(A192P,)Tj
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(and)Tj
1.7291 0 Td
(a)Tj
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(colony)Tj
2.9083 0 Td
(isolated)Tj
3.2825 0 Td
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(blood)Tj
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(cul-)Tj
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(ture)Tj
1.8425 0 Td
(of)Tj
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(an)Tj
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(animal)Tj
2.9651 0 Td
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4.0875 0 Td
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1.1792 0 Td
(A192P)Tj
2.8913 0 Td
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1.7008 0 Td
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4.4957 0 Td
(A192PP)Tj
3.4469 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
2.075 0 Td
(Inactivation)Tj
5.0456 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F9 1 Tf
-33.9531 -1.2982 Td
(A192PP)Tj
3.4469 0 Td
(genes)Tj
2.4434 0 Td
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(undertaken)Tj
4.8189 0 Td
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(phage)Tj
/F10 1 Tf
2.5909 0 Td
()Tj
/F9 1 Tf
0.7143 0 Td
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1.7915 0 Td
(recombinase)Tj
5.3064 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
2.0749 0 Td
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1.7859 0 Td
(primers)Tj
3.3505 0 Td
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1.0262 0 Td
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-35.4952 -1.2983 Td
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2.5001 0 Td
(mutants)Tj
3.5093 0 Td
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1.4456 0 Td
(shown)Tj
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0.83 0.64 0.02 0 k
1.0375 0 Td
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(1)Tj
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1.6271 0 Td
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[(\r)-13()14()7()20( )]TJ
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3.0727 0 Td
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(15)Tj
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(h)Tj
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Q
q
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BT
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1 TL
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[()]TJ
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(21)Tj
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(.)Tj
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0.9921 0 Td
[()7( )10(\n)12()]TJ
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(\(MH\))Tj
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5.0626 0 Td
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576 737.1 m
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36 737.6 l
576 737.6 l
f*
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107.0929 0 0 23.6409 36 741.3165 cm
q
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Q
Q
Q
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1.0418 0 Td
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(ONE)Tj
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(DOI:10.137)Tj
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36.7515 0 Td
(2)Tj
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128.2961 707.6409 l
h
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71.8299 674.6457 m
159.3071 674.6457 l
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36 663.6472 m
73.7008 663.6472 l
h
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7.9999 0 0 7.9999 36 708.7181 cm
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2.9764 0 Td
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(http://ww)Tj
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3.5929 0.0284 Td
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(http://www.)Tj
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(agence-nation)Tj
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