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Maboni, G., Blanchard, A. 
ORCID: 0000-0001-6991-7210, Frosth, S., Stewart, C., Emes, R. ORCID: 0000-0001-6855-5481 and Tötemeyer, S.,
2017.
A distinct bacterial dysbiosis associated skin inflammation in ovine footrot.
Scientific Reports, 7 (1): 45220.
ISSN 2045-2322
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Abstract
Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high D. nodosus load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation. Treponema (34%), Mycoplasma (29%) and Porphyromonas (15%) were the most abundant genera associated with high levels of inflammation in footrot. In contrast, Acinetobacter (25%), Corynebacteria (17%) and Flavobacterium (17%) were the most abundant genera associated with high levels of inflammation in healthy feet. This demonstrates for the first time there is a distinct microbial community associated with footrot and high cytokine expression.
| Item Type: | Journal article | ||||||
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| Publication Title: | Scientific Reports | ||||||
| Creators: | Maboni, G., Blanchard, A., Frosth, S., Stewart, C., Emes, R. and Tötemeyer, S. | ||||||
| Publisher: | Nature Publishing Group | ||||||
| Date: | 24 March 2017 | ||||||
| Volume: | 7 | ||||||
| Number: | 1 | ||||||
| ISSN: | 2045-2322 | ||||||
| Identifiers: |
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| Rights: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | ||||||
| Divisions: | Schools > School of Animal, Rural and Environmental Sciences | ||||||
| Record created by: | Linda Sullivan | ||||||
| Date Added: | 16 Aug 2018 11:08 | ||||||
| Last Modified: | 08 Feb 2023 12:00 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/34342 |
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