Type 2 diabetes – an autoinflammatory disease driven by metabolic stress

Gonzalez, L.L., Garrie, K. and Turner, M.D. ORCID: 0000-0001-7175-1053, 2018. Type 2 diabetes – an autoinflammatory disease driven by metabolic stress. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1864 (11), pp. 3805-3823. ISSN 0925-4439

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Abstract

Type 2 diabetes has traditionally been viewed as a metabolic disorder characterised by chronic high glucose levels, insulin resistance, and declining insulin secretion from the pancreas. Modern lifestyle, with abundant nutrient supply and reduced physical activity, has resulted in dramatic increases in the rates of obesity-associated disease conditions, including diabetes. The associated excess of nutrients induces a state of systemic low-grade chronic inflammation that results from production and secretion of inflammatory mediators from the expanded pool of activated adipocytes. Here, we review the mechanisms by which obesity induces adipose tissue dysregulation, detailing the roles of adipose tissue secreted factors and their action upon other cells and tissues central to glucose homeostasis and type 2 diabetes. Furthermore, given the emerging importance of adipokines, cytokines and chemokines in disease progression, we suggest that type 2 diabetes should now be viewed as an autoinflammatory disease, albeit one that is driven by metabolic dysregulation.

Item Type: Journal article
Publication Title: Biochimica et Biophysica Acta - Molecular Basis of Disease
Creators: Gonzalez, L.L., Garrie, K. and Turner, M.D.
Publisher: Elsevier
Date: November 2018
Volume: 1864
Number: 11
ISSN: 0925-4439
Identifiers:
NumberType
10.1016/j.bbadis.2018.08.034DOI
S0925443918303272Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 27 Sep 2018 08:40
Last Modified: 29 Aug 2019 03:00
URI: http://irep.ntu.ac.uk/id/eprint/34589

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