Tools
Tools
Betz, L.T., Brambilla, P., Ilankovic, A., Premkumar, P. 
ORCID: 0000-0003-1934-6741, Kim, M.-S., Raffard, S., Bayard, S., Hori, H., Lee, K.-U., Lee, S.J., Koutsouleris, N. and Kambeitz, J.,
2018.
Deciphering reward-based decision-making in schizophrenia: a meta-analysis and behavioral modeling of the Iowa Gambling Task.
Schizophrenia Research.
ISSN 0920-9964
|
Text
12133_1144a_Premkumar.pdf - Post-print Download (563kB) | Preview |
Abstract
Background: Patients with schizophrenia (SZP) have been reported to exhibit impairments in reward-based decision-making, but results are heterogeneous with multiple potential confounds such as age, intelligence level, clinical symptoms or medication, making it difficult to evaluate the robustness of these impairments.
Methods: We conducted a meta-analysis of studies comparing the performance of SZP and healthy controls (HC) in the Iowa Gambling Task (IGT) as well as comprehensive analyses based on subject-level data (n = 303 SZP, n = 188 HC) to investigate reward-based decision-making in SZP. To quantify differences in the influence of individual deck features (immediate gain, gain frequency, net loss) between SZP and HC, we additionally employed a least-squares model.
Results: SZP showed statistically significant suboptimal decisions as indicated by disadvantageous deck choices (d from 0.51 to −0.62) and lower net scores (d from −0.35 to −1.03) in a meta-analysis of k = 29 samples (n = 1127 SZP, n = 1149 HC) and these results were confirmed in a complementary subject-level analysis. Moreover, decision-making in SZP was characterized by a relative overweighting of immediate gain and net losses and an underweighting of gain frequency. Moderator analyses revealed that in part, decision-making in the IGT was moderated by intelligence level, medication and general symptom scores.
Conclusion: Our results indicate robust impairments in reward-based decision-making in SZP and suggest that decreased cognitive resources, such as working memory, may contribute to these alterations.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Schizophrenia Research | ||||||
| Creators: | Betz, L.T., Brambilla, P., Ilankovic, A., Premkumar, P., Kim, M.-S., Raffard, S., Bayard, S., Hori, H., Lee, K.-U., Lee, S.J., Koutsouleris, N. and Kambeitz, J. | ||||||
| Publisher: | Elsevier | ||||||
| Date: | 25 September 2018 | ||||||
| ISSN: | 0920-9964 | ||||||
| Identifiers: |
|
||||||
| Divisions: | Schools > School of Social Sciences | ||||||
| Record created by: | Linda Sullivan | ||||||
| Date Added: | 09 Oct 2018 10:51 | ||||||
| Last Modified: | 30 Oct 2018 13:45 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/34625 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
