Selective drug delivery approaches to lesioned brain through blood brain barrier disruption

Al-Ahmady, Z.S. ORCID: 0000-0001-7681-3735, 2018. Selective drug delivery approaches to lesioned brain through blood brain barrier disruption. Expert Opinion on Drug Delivery, 15 (4), pp. 335-349. ISSN 1742-5247

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Abstract

Introduction: The development of therapeutics for central nervous system (CNS) disorders is still considered a challenging area in drug development due to insufficient translocation through the blood-brain barrier (BBB). Under normal conditions, BBB restrict the penetration of more than 98% of blood-borne molecules including drugs to the CNS. However, recent research findings have proven that the nature of the BBB is altered in several neurological conditions. This complexity encourages revisiting drug delivery strategies to the CNS as this can give a wide range of opportunities for CNS drug development.

Areas covered: This review focuses on nanotechnology-based drug delivery platforms designed for selective recruitment into the lesioned brain by taking advantages of BBB disruption that is associated with certain neurological conditions.

Expert opinion: Current CNS therapeutic strategies do not fully address the pathophysiological adaptation of BBB in their design. The lack of selective delivery to the brain lesions has been the culprit behind the failure of many CNS therapeutics. This highlighted the need for smart designs of advanced drug delivery systems that take advantage of BBB structural changes in CNS diseases. Recently, promising examples have been reported in this area, however, more work is still required beyond the preclinical testing.

Item Type: Journal article
Publication Title: Expert Opinion on Drug Delivery
Creators: Al-Ahmady, Z.S.
Publisher: Taylor & Francis
Date: 2018
Volume: 15
Number: 4
ISSN: 1742-5247
Identifiers:
NumberType
10.1080/17425247.2018.1444601DOI
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 09 Nov 2018 14:15
Last Modified: 01 Mar 2019 03:00
URI: http://irep.ntu.ac.uk/id/eprint/34887

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