Engineering thermosensitive liposome-nanoparticle hybrids loaded with doxorubicin for heat-triggered drug release

Al-Ahmady, Z. ORCID: 0000-0001-7681-3735, Lozano, N., Mei, K.-C., Al-Jamal, W.T. and Kostarelos, K., 2016. Engineering thermosensitive liposome-nanoparticle hybrids loaded with doxorubicin for heat-triggered drug release. International Journal of Pharmaceutics, 514 (1), pp. 133-141. ISSN 0378-5173

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Abstract

The engineering of responsive multifunctional delivery systems that combine therapeutic and diagnostic (theranostic) capabilities holds great promise and interest. We describe the design of thermosensitive liposome-nanoparticle (NP) hybrids that can modulate drug release in response to external heating stimulus. These hybrid systems were successfully engineered by the incorporation of gold, silver, and iron oxide NPs into the lipid bilayer of lysolipid-containing thermosensitive liposomes (LTSL). Structural characterization of LTSL-NP hybrids using cryo-EM and AFM revealed the incorporation of metallic NPs into the lipid membranes without compromising doxorubicin loading and retention capability. The presence of metallic NPs in the lipid bilayer reinforced bilayer retention and offered a nanoparticle concentration-dependent modulation of drug release in response to external heating. In conclusion, LTSL-NP hybrids represent a promising versatile platform based on LTSL liposomes that could further utilize the properties of the embedded NPs for multifunctional theranostic applications.

Item Type: Journal article
Publication Title: International Journal of Pharmaceutics
Creators: Al-Ahmady, Z., Lozano, N., Mei, K.-C., Al-Jamal, W.T. and Kostarelos, K.
Publisher: Elsevier
Date: 30 November 2016
Volume: 514
Number: 1
ISSN: 0378-5173
Identifiers:
NumberType
10.1016/j.ijpharm.2016.09.009DOI
S0378517316308304Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 15 Nov 2018 12:03
Last Modified: 04 Dec 2018 12:55
URI: http://irep.ntu.ac.uk/id/eprint/34997

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