Spatiotemporal behaviour of high dominant frequency during persistent atrial fibrillation

Dastagir, N., Salinet, J., Vanheusden, F.J. ORCID: 0000-0003-2369-6189, Almeida, T.P., Li, X., Chu, G.S., Ng, G.A. and Schlindwein, F.S., 2014. Spatiotemporal behaviour of high dominant frequency during persistent atrial fibrillation. In: A. Murray, ed., Computing in Cardiology 2014. Computing in Cardiology, 41 . Piscataway, N.J.: IEEE, pp. 653-656. ISBN 9781479943463

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Abstract

Atrial electrograms (EGMs) with high dominant frequency (DF) are believed to represent atrial substrates with periodic activation responsible for the maintenance of persistent atrial fibrillation (persAF). This study aimed to assess the DF spatiotemporal behavior using high density noncontact mapping in persAF. For 8 patients undergoing left atrial (LA) persAF ablation, 2048 noncontact virtual unipolar EGMs were simultaneously collected and after the removal of ventricular far-field activity, Fourier based spectral analysis was used to identify DF on each EGM. Atrial areas with the highest DF (HDF, DF ± 0.25 Hz) were delimited in each frame for all EGMs, creating HDF `clouds'. Cumulative HDF clouds found at each frame were counted in the 3-D LA representation. To further assess the temporal stability of the cloud, the number of EGMs not hosting any HDF was determined for each window over time. The results show the number of occurrences of HDF clouds in the LA. The temporal behavior was analyzed by counting the number of positions on the 3-D representation of the LA not visited by HDF along time. Our results show HDF in persAF is not temporally stable and spatial distribution throughout the atria suggests the existence of driver regions with very rapid and regular activity maintaining AF. Therefore mapping the cumulative HDF might be an interesting strategy for ablation.

Item Type:	Chapter in book
Description:	Paper presented at 2014 Computing in Cardiology Conference (CinC), Cambridge, MA, USA, 7-10 September 2014.
Creators:	Dastagir, N., Salinet, J., Vanheusden, F.J., Almeida, T.P., Li, X., Chu, G.S., Ng, G.A. and Schlindwein, F.S.
Publisher:	IEEE
Place of Publication:	Piscataway, N.J.
Date:	September 2014
Volume:	41
ISBN:	9781479943463
ISSN:	0276-6574
Rights:	Articles in this volume are copyright (C) 2014 by their respective authors, and are licensed by their authors under the Creative Commons Attribution License 2.5 (CCAL).
Divisions:	Schools > School of Science and Technology
Record created by:	Jill Tomkinson
Date Added:	12 Dec 2018 16:38
Last Modified:	12 Dec 2018 17:18
URI:	https://irep.ntu.ac.uk/id/eprint/35313

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