Postsynthetic modification of phenylalanine containing peptides by C–H functionalization

Terrey, M.J., Perry, C.C. ORCID: 0000-0003-1517-468X and Cross, W.B. ORCID: 0000-0001-6277-400X, 2019. Postsynthetic modification of phenylalanine containing peptides by C–H functionalization. Organic Letters, 21 (1), pp. 104-108. ISSN 1523-7060

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Abstract

New methods for peptide modification are in high demand in drug discovery, chemical biology, and materials chemistry; methods that modify natural peptides are particularly attractive. A Pd-catalyzed, C–H functionalization protocol for the olefination of phenylalanine residues in peptides is reported, which is compatible with common amino acid protecting groups, and the scope of the styrene reaction partner is broad. Bidentate coordination of the peptide to the catalyst appears crucial for the success of the reaction.

Item Type: Journal article
Publication Title: Organic Letters
Creators: Terrey, M.J., Perry, C.C. and Cross, W.B.
Publisher: American Chemical Society
Date: January 2019
Volume: 21
Number: 1
ISSN: 1523-7060
Identifiers:
NumberType
10.1021/acs.orglett.8b03536DOI
Rights: Copyright © 2018 American Chemical Society
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 20 Dec 2018 16:24
Last Modified: 13 Dec 2019 03:00
URI: http://irep.ntu.ac.uk/id/eprint/35410

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