Cytokine, glycemic and insulinemic responses to an acute bout of games-based activity in adolescents

Dring, K.J. ORCID: 0000-0002-9647-3579, Cooper, S.B. ORCID: 0000-0001-5219-5020, Morris, J.G. ORCID: 0000-0001-6508-7897, Sunderland, C. ORCID: 0000-0001-7484-1345, Foulds, G.A. ORCID: 0000-0002-2053-7580, Pockley, A.G. ORCID: 0000-0001-9593-6431 and Nevill, M.E. ORCID: 0000-0003-2498-9493, 2019. Cytokine, glycemic and insulinemic responses to an acute bout of games-based activity in adolescents. Scandinavian Journal of Medicine & Science in Sports, 29 (4), pp. 597-605. ISSN 0905-7188

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Abstract

An acute bout of endurance exercise in adults stimulates a same‐day anti‐inflammatory response which may affect low‐grade chronic inflammation and insulin resistance and benefit cardio‐metabolic health. The anti‐inflammatory responses to intermittent games‐based exercise and to exercise in young people beyond 2‐h post‐exercise are unknown. Thus, the purpose of the present study is to examine the anti‐inflammatory, glycemic and insulinemic response to games‐based activity in adolescents. Following ethical approval and familiarization, 39 adolescents (12.3±0.7 y) completed an exercise (E) and rested (R) trial in a counterbalanced, randomized crossover design. Following a standardized breakfast, participants completed 1‐h games‐based activity. Capillary blood samples were taken at baseline, immediately and 1‐h post‐exercise and 30, 60 and 120‐min following a standardized lunch. A final blood sample was taken the next morning. Data were analyzed using repeated measures ANOVA. IL‐6 concentration was higher on day one of the exercise trial (E:3.4±0.4, R:2.7±0.4 pg.mL−1; p=0.006), as was the anti‐inflammatory IL‐6:TNF‐α ratio (E:5.53±0.93, R:3.75±0.45; p=0.027). Levels of the anti‐inflammatory cytokine IL‐10 increased on day two of the exercise trial (E:2.11±0.23, R:1.66±0.16 pg.mL−1; p=0.032). Insulin sensitivity was enhanced on the exercise trial with a reduction in iAUC following the standardized lunch (E:2310±834, R:3122±1443 mU.L−1x120 min; p<0.001). Games‐based activity stimulated an anti‐inflammatory response up to 24 h post‐exercise and improved insulin sensitivity in response to a standardized meal in healthy adolescents. These novel findings suggest that games‐based activity is an ecologically valid mode of exercise to elicit beneficial effects on cardio‐metabolic risk factors in young people.

Item Type: Journal article
Publication Title: Scandinavian Journal of Medicine & Science in Sports
Creators: Dring, K.J., Cooper, S.B., Morris, J.G., Sunderland, C., Foulds, G.A., Pockley, A.G. and Nevill, M.E.
Publisher: Wiley-Blackwell
Date: April 2019
Volume: 29
Number: 4
ISSN: 0905-7188
Identifiers:
NumberType
10.1111/sms.13378DOI
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 04 Jan 2019 15:34
Last Modified: 23 Dec 2019 03:00
URI: http://irep.ntu.ac.uk/id/eprint/35471

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