The development of novel electroanalytical interfaces for point of care diagnostics

Newton, LAA, 2012. The development of novel electroanalytical interfaces for point of care diagnostics. PhD, Nottingham Trent University.

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Abstract

Reduced sulphydryl thiols (RSH): cysteine, homocysteine and glutathione are fundamental cellular components having important biological functions, including roles within the pathogenesis of a variety of clinical conditions. Independent analysis of these species is problematic and analytical difficulties relating to instrumental selectivity and sensitivity need to be overcome. This thesis describes the work carried out on the development and characterisation of a range of systems that could be used to facilitate thiol detection, ideally at the point-of-care, focussing largely on electrochemical techniques. Silver-thiol interactions were studied as a route to assist the sample processing. Here a novel controlled silver release mechanism was assessed. Silver release was found to be dependent upon the thiol structure. This has possible future applications to the development of methods to prevent biofilm formation, although the full mechanism of silver-thiol release requires further understanding. The development of unique molecular imprinted polymers was attempted. These would facilitate the detection of amino acids and the relevant thiol species via the amine functionality.

Item Type: Thesis
Creators: Newton, L.A.A.
Date: 2012
Rights: This work is the intellectual property of the author, and may also be owned by the research sponsor(s) and / or Nottingham Trent University. You may copy up to 5% of this work for private study, or personal, non commercial research. Any re-use of the information contained within this document should be fully referenced, quoting the author, title, university, degree level and pagination. Queries or requests for any other use, or if a more substantial copy is required, should be directed in the first instance to the owner(s) of the Intellectual Property Rights.
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 09:36
Last Modified: 09 Oct 2015 09:36
URI: http://irep.ntu.ac.uk/id/eprint/355

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