Short poly-glutamine repeat in the androgen receptor in New World monkeys

Hiramatsu, C., Paukner, A. ORCID: 0000-0002-3421-1864, Kuroshima, H., Fujita, K., Suomi, S.J. and Inoue-Murayama, M., 2017. Short poly-glutamine repeat in the androgen receptor in New World monkeys. Meta Gene, 14, pp. 105-113. ISSN 2214-5400

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Abstract

The androgen receptor mediates various physiological and developmental functions and is highly conserved in mammals. Although great intraspecific length polymorphisms in poly glutamine (poly-Q) and poly glycine (poly-G) regions of the androgen receptor in humans, apes and several Old World monkeys have been reported, little is known about the characteristics of these regions in New World monkeys. In this study, we surveyed 17 species of New World monkeys and found length polymorphisms in these regions in three species (common squirrel monkeys, tufted capuchin monkeys and owl monkeys). We found that the poly-Q region in New World monkeys is relatively shorter than that in catarrhines (humans, apes and Old World monkeys). In addition, we observed that codon usage for poly-G region in New World monkeys is unique among primates. These results suggest that the length of polymorphic regions in androgen receptor genes have evolved uniquely in New World monkeys.

Item Type: Journal article
Publication Title: Meta Gene
Creators: Hiramatsu, C., Paukner, A., Kuroshima, H., Fujita, K., Suomi, S.J. and Inoue-Murayama, M.
Publisher: Elsevier
Date: 2017
Volume: 14
ISSN: 2214-5400
Identifiers:
NumberType
10.1016/j.mgene.2017.08.006DOI
S2214540017300695Publisher Item Identifier
Divisions: Schools > School of Social Sciences
Depositing User: Jonathan Gallacher
Date Added: 25 Jan 2019 13:45
Last Modified: 29 Mar 2019 09:38
URI: http://irep.ntu.ac.uk/id/eprint/35689

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