Community exercise is feasible for neuromuscular diseases and can improve aerobic capacity

Wallace, A., Pietrusz, A., Dewar, E., Dudziec, M., Jones, K., Hennis, P. ORCID: 0000-0002-8216-998X, Sterr, A., Baio, G., Machado, P., Laurá, M., Skorupinska, I., Skorupinska, M., Butcher, K., Trenell, M., Reilly, M.M., Hanna, M. and Ramdharry, G.M., 2019. Community exercise is feasible for neuromuscular diseases and can improve aerobic capacity. Neurology, 92 (15), e1773-e1785. ISSN 0028-3878

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Abstract

Objective: The aim of this phase 2 trial was to ascertain the feasibility and effect of community based aerobic exercise training for people with two of the more common neuromuscular diseases: Charcot-Marie-Tooth disease type 1A (CMT) and Inclusion Body Myositis (IBM).

Methods: A randomised single blinded cross over trial design was used to compare a 12-week aerobic training programme using recombinant exercise bicycles compared to a control period. The training occurred three times per week in community gyms local to the participants. Support was available from trained gym staff and a research physiotherapist. The two disease groups were analysed separately. The primary outcome measure was peak oxygen uptake (VO2 peak) during a maximal exercise test, with secondary measures of muscle strength, function and patient reported measures.

Results: Data from 23 people with CMT and 17 people with IBM was included in the analysis. Both disease groups had high levels of participation and demonstrated improvements in VO2 peak, with a moderate effect size in the CMT participants (Cohen’s d = 0.53) and a strong effect size in the IBM group (Cohen’s d = 1.72). No major changes were observed in the secondary outcome measures. Qualitative interviews revealed that participants valued the support of gym instructors and the research physiotherapists in overcoming challenges to participation.

Conclusion: Twelve weeks of aerobic training in community gyms was feasible, safe and improved aerobic capacity in people with CMT and IBM.

Classification of Evidence: This study provides Class II evidence that for patients with CMT type 1A and IBM, an aerobic training program increases aerobic capacity.

Item Type: Journal article
Publication Title: Neurology
Creators: Wallace, A., Pietrusz, A., Dewar, E., Dudziec, M., Jones, K., Hennis, P., Sterr, A., Baio, G., Machado, P., Laurá, M., Skorupinska, I., Skorupinska, M., Butcher, K., Trenell, M., Reilly, M.M., Hanna, M. and Ramdharry, G.M.
Publisher: Lippincott Williams & Wilkins
Date: 9 April 2019
Volume: 92
Number: 15
ISSN: 0028-3878
Identifiers:
NumberType
10.1212/wnl.0000000000007265DOI
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 26 Feb 2019 09:40
Last Modified: 22 Oct 2019 15:32
URI: http://irep.ntu.ac.uk/id/eprint/35805

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