Impaired glucose tolerance in adults with Duchenne and Becker muscular dystrophy

Bostock, E.L. ORCID: 0000-0001-9340-8459, Edwards, B.T., Jacques, M.F., Pogson, J.T.S., Reeves, N.D., Onambele-Pearson, G.L. and Morse, C.I., 2018. Impaired glucose tolerance in adults with Duchenne and Becker muscular dystrophy. Nutrients, 10 (12): 1947. ISSN 2072-6643

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Abstract

The aim of this study was to determine the response to an oral glucose tolerance test (OGTT) in adult males with Becker muscular dystrophy (BMD) and Duchenne muscular dystrophy (DMD), and to investigate whether body composition contributes to any variance in the glucose response. Twenty-eight adult males with dystrophinopathy (BMD, n = 13; DMD, n = 15) and 12 non-dystrophic controls, ingested 75 g oral anhydrous glucose solution. Fingertip capillary samples were assessed for glucose at 30-min intervals over 2-h post glucose ingestion. Fat free mass relative to body mass (FFM/BM) and body fat (BF%) was assessed using bioelectrical impedance. Vastus lateralis muscle anatomical cross sectional area (VL ACSA) was measured using B-mode ultrasonography. Blood glucose was higher in MD groups than control at 60, 90 and 120 min post ingestion of glucose. Compared to controls, FFM/BM and VL ACSA were lower in MD groups compared to controls (p < 0.001). Glucose tolerance values at 120 min were correlated with FFM/BM and BF% in the BMD group only. Our results suggest that glucose tolerance is impaired following OGTT in adult males with BMD and DMD. It is recommended that adults with BMD and DMD undertake routine glucose tolerance assessments to allow early detection of impaired glucose tolerance.

Item Type: Journal article
Publication Title: Nutrients
Creators: Bostock, E.L., Edwards, B.T., Jacques, M.F., Pogson, J.T.S., Reeves, N.D., Onambele-Pearson, G.L. and Morse, C.I.
Publisher: MDPI
Date: 7 December 2018
Volume: 10
Number: 12
ISSN: 2072-6643
Identifiers:
NumberType
10.3390/nu10121947DOI
nu10121947Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 27 Feb 2019 14:04
Last Modified: 27 Feb 2019 14:34
URI: http://irep.ntu.ac.uk/id/eprint/35833

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