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Morse, C.I., Bostock, E.L. 
ORCID: 0000-0001-9340-8459, Twiss, H.M., Kapp, L.H., Orme, P. and Jacques, M.F.,
2018.
The cardiorespiratory response and physiological determinants of the assisted 6-minute handbike cycle test in adult males with muscular dystrophy.
Muscle & Nerve, 58 (3), pp. 427-433.
ISSN 0148-639X
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Abstract
Introduction: The assisted 6-minute cycle test (A6MCT) distance was assessed in adults with muscular dystrophy (MD).
Methods: Forty-eight males, including those with Duchenne MD (DMD), limb-girdle MD (LGMD), fascioscapulohumeral MD (FSHD), and Becker MD (BMD), as well as a group without MD (CTRL), completed handgrip strength (HGS), lung function [forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC)], body fat, and biceps thickness assessments. During the A6MCT, ventilation (VE), oxygen uptake (VO2), carbon dioxide (VCO2), and heart rate (HR) were recorded.
Results: A6MCT and HGS were lower in MD than CTRL subjects. FEV1, FVC, and biceps thickness were lower in MD than CTRL; lower in DMD than BMD, LGMD, and FSHD; but were not different between BMD, LGMD, and FSHD. A6MCT correlated with HGS, FEV1, FVC, body fat, VO2, VCO2, HR, and VE (r 5 0.455–0.708) in pooled BMD, LGMD, and FSHD participants.
Discussion: A shorter A6MCT distance in adult males with MD was attributable to HGS and lung function. The A6MCT is appropriate for assessment of physical function in adults with MD.
| Item Type: | Journal article | ||||
|---|---|---|---|---|---|
| Publication Title: | Muscle & Nerve | ||||
| Creators: | Morse, C.I., Bostock, E.L., Twiss, H.M., Kapp, L.H., Orme, P. and Jacques, M.F. | ||||
| Publisher: | Wiley Periodicals, Inc. | ||||
| Date: | September 2018 | ||||
| Volume: | 58 | ||||
| Number: | 3 | ||||
| ISSN: | 0148-639X | ||||
| Identifiers: |
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| Rights: | This is an open access article under the terms of the Creative CommonsAttribution-NonCommercial License, which permits use, distribution andreproduction in any medium, provided the original work is properly citedand is not used for commercial purposes. | ||||
| Divisions: | Schools > School of Science and Technology | ||||
| Record created by: | Jill Tomkinson | ||||
| Date Added: | 27 Feb 2019 16:00 | ||||
| Last Modified: | 27 Feb 2019 16:00 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/35837 |
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