Tools
Tools
Vikulina, A.S. 
ORCID: 0000-0001-9427-2055, Skirtach, A.G. and Volodkin, D. ORCID: 0000-0001-7474-5329,
2019.
Hybrids of polymer multilayers, lipids, and nanoparticles: mimicking the cellular microenvironment.
Langmuir, 35 (26), pp. 8565-8573.
ISSN 0743-7463
|
Text
13881_Volodkin.pdf - Published version Download (7MB) | Preview |
Abstract
Here we address research directions and trends developed following novel concepts in 2D/3D self-assembled polymer structures established in the department led by Helmuth Möhwald. These functional structures made of hybrids of polymer multilayers, lipids, and nanoparticles stimulated research in the design of the cellular microenvironment. The composition of the extracellular matrix (ECM) and dynamics of biofactor presentation in the ECM can be recapitulated by the hybrids. Proteins serve as models for protein-based biofactors such as growth factors, cytokines, hormones, and so forth. A fundamental understanding of complex intermolecular interactions and approaches developed for the externally IR-light-triggered release offers a powerful tool for controlling the biofactor presentation. Pure protein beads made via a mild templating on vaterite CaCO3 crystals can mimic cellular organelles in terms of the compartmentalization of active proteins. We believe that an integration of the approaches developed and described here offers a strong tool for engineering and mimicking both extra- and intracellular microenvironments.
| Item Type: | Journal article | ||||
|---|---|---|---|---|---|
| Publication Title: | Langmuir | ||||
| Creators: | Vikulina, A.S., Skirtach, A.G. and Volodkin, D. | ||||
| Publisher: | American Chemical Society | ||||
| Date: | 2 July 2019 | ||||
| Volume: | 35 | ||||
| Number: | 26 | ||||
| ISSN: | 0743-7463 | ||||
| Identifiers: |
|
||||
| Rights: | Copyright © 2019 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. | ||||
| Divisions: | Schools > School of Science and Technology | ||||
| Record created by: | Jonathan Gallacher | ||||
| Date Added: | 03 May 2019 09:28 | ||||
| Last Modified: | 02 Jul 2021 10:40 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/36406 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
