Hybrids of polymer multilayers, lipids, and nanoparticles: mimicking the cellular microenvironment

Vikulina, A.S. ORCID: 0000-0001-9427-2055, Skirtach, A.G. and Volodkin, D. ORCID: 0000-0001-7474-5329, 2019. Hybrids of polymer multilayers, lipids, and nanoparticles: mimicking the cellular microenvironment. Langmuir. ISSN 0743-7463

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Abstract

Here we address research directions and trends developed following novel concepts in 2D/3D self-assembled polymer structures established in the department led by Helmuth Möhwald. These functional structures made of hybrids of polymer multilayers, lipids, and nanoparticles stimulated research in the design of the cellular microenvironment. The composition of the extracellular matrix (ECM) and dynamics of biofactor presentation in the ECM can be recapitulated by the hybrids. Proteins serve as models for protein-based biofactors such as growth factors, cytokines, hormones, and so forth. A fundamental understanding of complex intermolecular interactions and approaches developed for the externally IR-light-triggered release offers a powerful tool for controlling the biofactor presentation. Pure protein beads made via a mild templating on vaterite CaCO3 crystals can mimic cellular organelles in terms of the compartmentalization of active proteins. We believe that an integration of the approaches developed and described here offers a strong tool for engineering and mimicking both extra- and intracellular microenvironments.

Item Type: Journal article
Publication Title: Langmuir
Creators: Vikulina, A.S., Skirtach, A.G. and Volodkin, D.
Publisher: American Chemical Society
Date: 6 February 2019
ISSN: 0743-7463
Identifiers:
NumberType
10.1021/acs.langmuir.8b04328DOI
Rights: Copyright © 2019 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 03 May 2019 09:28
Last Modified: 06 Feb 2020 03:00
URI: http://irep.ntu.ac.uk/id/eprint/36406

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