Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study

Ikeda, S., Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Nakagawa, S., Sekiguchi, A., Iizuka, K., Hanawa, S., Araki, T., Miyauchi, C.M., Sakaki, K., Nozawa, T., Yokota, S., Magistro, D. ORCID: 0000-0002-2554-3701 and Kawashima, R., 2019. Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study. Brain and Behavior. ISSN 2162-3279

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Abstract

Introduction: Self- and external-preoccupation have been linked to psychopathological states. The neural substrates underlying self- and external-preoccupation remain unclear. In the present study, we aim to provide insight into the information-processing mechanisms associated with self- and external-preoccupation at the structural level.

Methods: To investigate the neural substrates of self- and external-preoccupation, we acquired high-resolution T1-weighted structural images and Preoccupation Scale scores from 1,122 young subjects. Associations between regional gray matter volume (rGMV) and Preoccupation Scale subscores for self- and external-preoccupation were estimated using voxel-based morphometry.

Results: Significant positive associations between self-preoccupation and rGMV were observed in widespread brain areas such as the bilateral precuneus and posterior cingulate gyri, structures known to be associated with self-triggered self-reference during rest. Significant negative associations between external-preoccupation and rGMV were observed only in the bilateral cerebellum, regions known to be associated with behavioral addiction, sustained attention, and reward system.

Conclusion: Our results reveal distinct neural substrates for self- and external-preoccupation at the structural level.

Item Type: Journal article
Publication Title: Brain and Behavior
Creators: Ikeda, S., Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Nakagawa, S., Sekiguchi, A., Iizuka, K., Hanawa, S., Araki, T., Miyauchi, C.M., Sakaki, K., Nozawa, T., Yokota, S., Magistro, D. and Kawashima, R.
Publisher: John Wiley
Date: 19 April 2019
ISSN: 2162-3279
Identifiers:
NumberType
10.1002/brb3.1267DOI
Rights: © 2019 the authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 09 May 2019 14:40
Last Modified: 09 May 2019 14:40
URI: http://irep.ntu.ac.uk/id/eprint/36449

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