Tools
Tools
Barber, I.S., Braae, A., Clement, N., Patel, T., Guetta-Baranes, T., Brookes, K. 
ORCID: 0000-0003-2427-2513, Medway, C., Chappell, S., Guerreiro, R., Bras, J., Hernandez, D., Singleton, A., Hardy, J., Mann, D.M., Morgan, K., Passmore, P., Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R., Kölsch, H., Kehoe, P.G., Vardy, E.R.L.C., Hooper, N.M., Pickering-Brown, S., Snowden, J., Richardson, A., Jones, M., Neary, D., Harris, J., Lowe, J., Smith, A.D., Wilcock, G., Warden, D. and Holmes, C.,
2017.
Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array.
Neurobiology of Aging, 49, 215.e1-215.e8.
ISSN 0197-4580
|
Text
13923_Brookes.pdf - Post-print Download (536kB) | Preview |
Abstract
We have screened sporadic early-onset Alzheimer's disease (sEOAD, n = 408) samples using the NeuroX array for known causative and predicted pathogenic variants in 16 genes linked to familial forms of neurodegeneration. We found 2 sEOAD individuals harboring a known causative variant in PARK2 known to cause early-onset Parkinson's disease; p.T240M (n = 1) and p.Q34fs delAG (n = 1). In addition, we identified 3 sEOAD individuals harboring a predicted pathogenic variant in MAPT (p.A469T), which has previously been associated with AD. It is currently unknown if these variants affect susceptibility to sEOAD, further studies would be needed to establish this. This work highlights the need to screen sEOAD individuals for variants that are more classically attributed to other forms of neurodegeneration.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Neurobiology of Aging | ||||||
| Creators: | Barber, I.S., Braae, A., Clement, N., Patel, T., Guetta-Baranes, T., Brookes, K., Medway, C., Chappell, S., Guerreiro, R., Bras, J., Hernandez, D., Singleton, A., Hardy, J., Mann, D.M., Morgan, K., Passmore, P., Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R., Kölsch, H., Kehoe, P.G., Vardy, E.R.L.C., Hooper, N.M., Pickering-Brown, S., Snowden, J., Richardson, A., Jones, M., Neary, D., Harris, J., Lowe, J., Smith, A.D., Wilcock, G., Warden, D. and Holmes, C. | ||||||
| Publisher: | Elsevier | ||||||
| Date: | January 2017 | ||||||
| Volume: | 49 | ||||||
| ISSN: | 0197-4580 | ||||||
| Identifiers: |
|
||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jonathan Gallacher | ||||||
| Date Added: | 15 May 2019 08:54 | ||||||
| Last Modified: | 15 May 2019 08:54 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/36545 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
