Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array

Barber, I.S., Braae, A., Clement, N., Patel, T., Guetta-Baranes, T., Brookes, K. ORCID: 0000-0003-2427-2513, Medway, C., Chappell, S., Guerreiro, R., Bras, J., Hernandez, D., Singleton, A., Hardy, J., Mann, D.M., Morgan, K., Passmore, P., Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R., Kölsch, H., Kehoe, P.G., Vardy, E.R.L.C., Hooper, N.M., Pickering-Brown, S., Snowden, J., Richardson, A., Jones, M., Neary, D., Harris, J., Lowe, J., Smith, A.D., Wilcock, G., Warden, D. and Holmes, C., 2017. Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array. Neurobiology of Aging, 49, 215.e1-215.e8. ISSN 0197-4580

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Abstract

We have screened sporadic early-onset Alzheimer's disease (sEOAD, n = 408) samples using the NeuroX array for known causative and predicted pathogenic variants in 16 genes linked to familial forms of neurodegeneration. We found 2 sEOAD individuals harboring a known causative variant in PARK2 known to cause early-onset Parkinson's disease; p.T240M (n = 1) and p.Q34fs delAG (n = 1). In addition, we identified 3 sEOAD individuals harboring a predicted pathogenic variant in MAPT (p.A469T), which has previously been associated with AD. It is currently unknown if these variants affect susceptibility to sEOAD, further studies would be needed to establish this. This work highlights the need to screen sEOAD individuals for variants that are more classically attributed to other forms of neurodegeneration.

Item Type: Journal article
Publication Title: Neurobiology of Aging
Creators: Barber, I.S., Braae, A., Clement, N., Patel, T., Guetta-Baranes, T., Brookes, K., Medway, C., Chappell, S., Guerreiro, R., Bras, J., Hernandez, D., Singleton, A., Hardy, J., Mann, D.M., Morgan, K., Passmore, P., Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R., Kölsch, H., Kehoe, P.G., Vardy, E.R.L.C., Hooper, N.M., Pickering-Brown, S., Snowden, J., Richardson, A., Jones, M., Neary, D., Harris, J., Lowe, J., Smith, A.D., Wilcock, G., Warden, D. and Holmes, C.
Publisher: Elsevier
Date: January 2017
Volume: 49
ISSN: 0197-4580
Identifiers:
NumberType
10.1016/j.neurobiolaging.2016.09.008DOI
S0197458016302214Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 15 May 2019 08:54
Last Modified: 15 May 2019 08:54
URI: http://irep.ntu.ac.uk/id/eprint/36545

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