Porous alginate scaffolds assembled using vaterite CaCO3 crystals

Sergeeva, A., Vikulina, A.S. ORCID: 0000-0001-9427-2055 and Volodkin, D. ORCID: 0000-0001-7474-5329, 2019. Porous alginate scaffolds assembled using vaterite CaCO3 crystals. Micromachines, 10 (6), p. 357. ISSN 2072-666X

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Abstract

Formulation of multifunctional biopolymer-based scaffolds is one of the major focuses in modern tissue engineering and regenerative medicine. Besides proper mechanical/chemical properties, an ideal scaffold should: (i) possess a well-tuned porous internal structure for cell seeding/growth and (ii) host bioactive molecules to be protected against biodegradation and presented to cells when required. Alginate hydrogels were extensively developed to serve as scaffolds, and recent advances in the hydrogel formulation demonstrate their applicability as “ideal” soft scaffolds. This review focuses on advanced porous alginate scaffolds (PAS) fabricated using hard templating on vaterite CaCO3 crystals. These novel tailor-made soft structures can be prepared at physiologically relevant conditions offering a high level of control over their internal structure and high performance for loading/release of bioactive macromolecules. The novel approach to assemble PAS is compared with traditional methods used for fabrication of porous alginate hydrogels. Finally, future perspectives and applications of PAS for advanced cell culture, tissue engineering, and drug testing are discussed.

Item Type: Journal article
Publication Title: Micromachines
Creators: Sergeeva, A., Vikulina, A.S. and Volodkin, D.
Publisher: MDPI AG
Date: 29 May 2019
Volume: 10
Number: 6
ISSN: 2072-666X
Identifiers:
NumberType
10.3390/mi10060357DOI
mi10060357Publisher Item Identifier
Rights: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 06 Jun 2019 09:48
Last Modified: 30 Jul 2019 14:26
URI: http://irep.ntu.ac.uk/id/eprint/36715

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