Yersinia adhesins: an arsenal for infection

Chauhan, N., Wrobel, A., Skurnik, M. and Leo, J.C. ORCID: 0000-0002-7066-7527, 2016. Yersinia adhesins: an arsenal for infection. Proteomics - Clinical Applications, 10 (9-10), pp. 949-963. ISSN 1862-8346

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Abstract

The Yersiniae are a group of Gram-negative coccobacilli inhabiting a wide range of habitats. The genus harbours three recognised human pathogens: Y. enterocolitica and Y. pseudotuberculosis, which both cause gastrointestinal disease, and Y. pestis, the causative agent of plague. These three organisms have served as models for a number of aspects of infection biology, including adhesion, immune evasion, evolution of pathogenic traits, and retracing the course of ancient pandemics. The virulence of the pathogenic Yersiniae is heavily dependent on a number of adhesin molecules. Some of these, such as the Yersinia adhesin A and invasin of the enteropathogenic species, and the pH 6 antigen of Y. pestis, have been extensively studied. However, genomic sequencing has uncovered a host of other adhesins present in these organisms, the functions of which are only starting to be investigated. Here, we review the current state of knowledge on the adhesin molecules present in the Yersiniae, their functions and putative roles in the infection process.

Item Type:	Journal article
Publication Title:	Proteomics - Clinical Applications
Creators:	Chauhan, N., Wrobel, A., Skurnik, M. and Leo, J.C.
Publisher:	WILEY-VCH Verlag GmbH & Co. KGaA
Date:	October 2016
Volume:	10
Number:	9-10
ISSN:	1862-8346
Identifiers:	Number Type 10.1002/prca.201600012 DOI
Divisions:	Schools > School of Science and Technology
Record created by:	Jill Tomkinson
Date Added:	19 Jun 2019 13:36
Last Modified:	25 Jun 2019 13:03
URI:	https://irep.ntu.ac.uk/id/eprint/36873

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