A unified model for BAM function that takes into account type Vc secretion and species differences in BAM composition

Leo, J.C. ORCID: 0000-0002-7066-7527 and Linke, D., 2018. A unified model for BAM function that takes into account type Vc secretion and species differences in BAM composition. AIMS Microbiology, 4 (3), pp. 455-468. ISSN 2471-1888

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Abstract

Transmembrane proteins in the outer membrane of Gram-negative bacteria are almost exclusively β-barrels. They are inserted into the outer membrane by a conserved and essential protein complex called the BAM (for β-barrel assembly machinery). In this commentary, we summarize current research into the mechanism of this protein complex and how it relates to type V secretion. Type V secretion systems are autotransporters that all contain a β-barrel transmembrane domain inserted by BAM. In type Vc systems, this domain is a homotrimer. We argue that none of the current models are sufficient to explain BAM function particularly regarding type Vc secretion. We also find that current models based on the well-studied model system Escherichia coli mostly ignore the pronounced differences in BAM composition between different bacterial species. We propose a more holistic view on how all OMPs, including autotransporters, are incorporated into the lipid bilayer.

Item Type: Journal article
Publication Title: AIMS Microbiology
Creators: Leo, J.C. and Linke, D.
Publisher: American Institute of Mathematical Sciences (AIMS) Press
Date: 2018
Volume: 4
Number: 3
ISSN: 2471-1888
Identifiers:
NumberType
10.3934/microbiol.2018.3.455DOI
Rights: © 2018 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 21 Jun 2019 08:28
Last Modified: 25 Jun 2019 13:02
URI: http://irep.ntu.ac.uk/id/eprint/36886

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