Differentiating the cognitive development of early-term births in infants and toddlers: a cross-sectional study in China

Hua, J., Sun, J., Cao, Z., Dai, X., Lin, S., Guo, J., Gu, G. and Du, W. ORCID: 0000-0002-5115-7214, 2019. Differentiating the cognitive development of early-term births in infants and toddlers: a cross-sectional study in China. BMJ Open, 9 (4), e025275. ISSN 2044-6055

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Abstract

Objectives:

This study aimed to explore the cognitive development of low-risk children during early childhood for early-term births at 37 and 38 weeks of gestation compared with full term births at 39–41 weeks of gestation.

Setting and participants:

We conducted a cross-sectional study in Shanghai, one of the largest cities in China. A total of 1444 children from singleton pregnancies born at term gestation were included in the study.

Measures:

The cognitive outcomes of the subjects were measured using the cognitive subtest of Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) across three cities in China. We analysed the association between gestational age and cognitive development during infancy and toddler stages using multivariate linear modelling.

Results:

The cognitive development scores for infants born at 37 gestational weeks were significantly lower than those born at 39–41 gestational weeks (β=−2.257, 95%CI −4.280 to −0.235; p<0.05) after adjusting for children’s and maternal characteristics, as well as socioeconomic factors. However, there were no significant differences in cognitive ability between infants born at 38 gestational weeks compared with their full-term counterparts (p>0.05). Moreover, these effects were not found in toddlers (between 17 and 48 months of age) after adjusting for the possible confounders (p>0.05).

Conclusions:

Infants born at 37 weeks of gestation exhibited weaker cognitive ability compared with those born at 39–41 weeks of gestation. Our findings provide evidences for the close monitoring of potential developmental problems in early-term children, especially those born at 37 gestational weeks.

Item Type: Journal article
Publication Title: BMJ Open
Creators: Hua, J., Sun, J., Cao, Z., Dai, X., Lin, S., Guo, J., Gu, G. and Du, W.
Publisher: BMJ Publishing Group
Date: July 2019
Volume: 9
Number: 4
ISSN: 2044-6055
Identifiers:
NumberType
10.1136/bmjopen-2018-025275DOI
Rights: © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Divisions: Schools > School of Social Sciences
Depositing User: Jill Tomkinson
Date Added: 15 Jul 2019 14:29
Last Modified: 15 Jul 2019 14:29
URI: http://irep.ntu.ac.uk/id/eprint/37078

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