Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine

Christian, M. ORCID: 0000-0002-1616-4179, 2015. Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine. Adipocyte, 4 (1), pp. 50-54. ISSN 2162-3945

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Abstract

Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis. The dissipation of energy in brown adipose tissue (BAT) is in stark contrast to white adipose tissue (WAT) which is the body's primary site of energy storage. However, adipose tissue is highly dynamic and upon cold exposure profound changes occur in WAT resulting in a BAT-like phenotype due to the presence of brown-in-white (BRITE) adipocytes. In our recent report, transcription profiling was used to identify the gene expression changes that underlie the browning process as well as the intrinsic differences between BAT and WAT. Neuregulin 4 was categorized as a cold-induced BAT gene encoding an adipokine that signals between adipocytes and nerve cells and likely to have a role in increasing adipose tissue innervation in response to cold.

Item Type: Journal article
Publication Title: Adipocyte
Creators: Christian, M.
Publisher: Taylor & Francis
Date: 2015
Volume: 4
Number: 1
ISSN: 2162-3945
Identifiers:
NumberType
10.4161/adip.29853DOI
Rights: © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC© Mark Christian.
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 08 Aug 2019 13:47
Last Modified: 08 Aug 2019 13:47
URI: http://irep.ntu.ac.uk/id/eprint/37197

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