Lipid droplet growth: regulation of a dynamic organelle

Barneda, D. and Christian, M. ORCID: 0000-0002-1616-4179, 2017. Lipid droplet growth: regulation of a dynamic organelle. Current Opinion in Cell Biology, 47, pp. 9-15. ISSN 0955-0674

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Abstract

Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulated storage and release of lipids to fulfil their fundamental roles in energy metabolism, membrane synthesis and provision of lipid-derived signaling molecules. Although small LDs are observed in all types of eukaryotic cells, it is adipocytes that present the widest range of sizes up to the massive unilocular droplet of a white adipocyte. Our knowledge of the proteins and associated processes that control LD dynamics is improving. The dynamic expression of LD-associated proteins is vital for controlling LD biology and is most apparent during adipocyte differentiation. Recent findings on the molecular mechanisms of lipid droplet enlargement reveal the importance of distinct functional groups of proteins and phospholipids.

Item Type: Journal article
Publication Title: Current Opinion in Cell Biology
Creators: Barneda, D. and Christian, M.
Publisher: Elsevier
Date: August 2017
Volume: 47
ISSN: 0955-0674
Identifiers:
NumberType
10.1016/j.ceb.2017.02.002DOI
S0955067416302125Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 12 Aug 2019 08:42
Last Modified: 12 Aug 2019 08:42
URI: http://irep.ntu.ac.uk/id/eprint/37219

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