A comprehensive combined experimental and computational framework for pre-clinical wear simulation of total knee replacements

Abdelgaied, A. ORCID: 0000-0003-0066-1688, Fisher, J. and Jennings, L.M., 2018. A comprehensive combined experimental and computational framework for pre-clinical wear simulation of total knee replacements. Journal of the Mechanical Behavior of Biomedical Materials, 78, pp. 282-291. ISSN 1751-6161

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Abstract

A more robust pre-clinical wear simulation framework is required in order to simulate wider and higher ranges of activities, observed in different patient populations such as younger more active patients. Such a framework will help to understand and address the reported higher failure rates for younger and more active patients (National_Joint_Registry, 2016). The current study has developed and validated a comprehensive combined experimental and computational framework for pre-clinical wear simulation of total knee replacements (TKR).

The input mechanical (elastic modulus and Poisson's ratio) and wear parameters of the moderately cross-linked ultra-high molecular weight polyethylene (UHMWPE) bearing material were independently measured from experimental studies under realistic test conditions, similar to the loading conditions found in the total knee replacements. The wear predictions from the computational wear simulation were validated against the direct experimental wear measurements for size 3 Sigma curved total knee replacements (DePuy, UK) in an independent experimental wear simulation study under three different daily activities; walking, deep squat, and stairs ascending kinematic conditions.

The measured compressive mechanical properties of the moderately cross-linked UHMWPE material were more than 20% lower than that reported in the literature under tensile test conditions. The pin-on-plate wear coefficient of moderately cross-linked UHMWPE was significantly dependant of the contact stress and the degree of cross-shear at the articulating surfaces.

The computational wear predictions for the TKR from the current framework were consistent and in a good agreement with the independent full TKR experimental wear simulation measurements, with 0.94 coefficient of determination of the framework. In addition, the comprehensive combined experimental and computational framework was able to explain the complex experimental wear trends from the three different daily activities investigated. Therefore, such a framework can be adopted as a pre-clinical simulation approach to optimise different designs, materials, as well as patient's specific total knee replacements for a range of activities.

Item Type: Journal article
Publication Title: Journal of the Mechanical Behavior of Biomedical Materials
Creators: Abdelgaied, A., Fisher, J. and Jennings, L.M.
Publisher: Elsevier
Date: February 2018
Volume: 78
ISSN: 1751-6161
Identifiers:
NumberType
10.1016/j.jmbbm.2017.11.022DOI
S1751616117305106Publisher Item Identifier
Rights: © 2017 Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 15 Aug 2019 08:59
Last Modified: 15 Aug 2019 08:59
URI: http://irep.ntu.ac.uk/id/eprint/37326

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