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Leo, J.C. 
ORCID: 0000-0002-7066-7527, Grin, I. and Linke, D.,
2012.
Type V secretion: mechanism(s) of autotransport through the bacterial outer membrane.
Philosophical Transactions of the Royal Society B: Biological Sciences, 367 (1592), pp. 1088-1101.
ISSN 0962-8436
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Abstract
Autotransport in Gram-negative bacteria denotes the ability of surface-localized proteins to cross the outer membrane (OM) autonomously. Autotransporters perform this task with the help of a β-barrel transmembrane domain localized in the OM. Different classes of autotransporters have been investigated in detail in recent years; classical monomeric but also trimeric autotransporters comprise many important bacterial virulence factors. So do the two-partner secretion systems, which are a special case as the transported protein resides on a different polypeptide chain than the transporter. Despite the great interest in these proteins, the exact mechanism of the transport process remains elusive. Moreover, different periplasmic and OM factors have been identified that play a role in the translocation, making the term 'autotransport' debatable. In this review, we compile the wealth of details known on the mechanism of single autotransporters from different classes and organisms, and put them into a bigger perspective. We also discuss recently discovered or rediscovered classes of autotransporters.
| Item Type: | Journal article | ||||
|---|---|---|---|---|---|
| Publication Title: | Philosophical Transactions of the Royal Society B: Biological Sciences | ||||
| Creators: | Leo, J.C., Grin, I. and Linke, D. | ||||
| Publisher: | The Royal Society Publishing | ||||
| Date: | 2012 | ||||
| Volume: | 367 | ||||
| Number: | 1592 | ||||
| ISSN: | 0962-8436 | ||||
| Identifiers: |
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| Rights: | This journal is © 2012 The Royal Society. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||||
| Divisions: | Schools > School of Science and Technology | ||||
| Record created by: | Linda Sullivan | ||||
| Date Added: | 11 Sep 2019 15:23 | ||||
| Last Modified: | 11 Sep 2019 15:32 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/37640 |
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