Mean diffusivity related to rule-breaking guilt: the Macbeth effect in the sensorimotor regions

Nakagawa, S., Takeuchi, H., Taki, Y., Nouchi, R., Kotozaki, Y., Shinada, T., Maruyama, T., Sekiguchi, A., Iizuka, K., Yokoyama, R., Yamamoto, Y., Hanawa, S., Araki, T., Makoto Miyauchi, C., Magistro, D. ORCID: 0000-0002-2554-3701, Sakaki, K., Jeong, H., Sasaki, Y. and Kawashima, R., 2019. Mean diffusivity related to rule-breaking guilt: the Macbeth effect in the sensorimotor regions. Scientific Reports, 9: 12227. ISSN 2045-2322

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Abstract

Guilt, a self-conscious emotion, includes self-focused role taking and also correlates with other-oriented role-taking. Excess guilt proneness might be relevant to obsessive compulsive disorders. The white matter (WM) neural correlates of the degree of guilt have not yet been determined. We hypothesized that the WM structures involved in feelings of guilt are associated with social and moral cognition (inferior parietal lobule [IPL], prefrontal cortex [PFC], and cingulate), and aimed to visualize this using diffusion MRI. We investigated the association between regional WM structures (WM volume, and fractional anisotropy, and mean diffusivity [MD]), and feelings of guilt in 1196 healthy, young students using MRI and the Guilty Feeling Scale, which comprises interpersonal situation (IPS; guilt from hurting friends) and rule-breaking situation (RBS; deontological guilt) scores. The primary novel finding presented here is that MD in the right somatosensory and motor cortices from arm to hand were positively correlated with RBS scores. Further, consistent with our hypothesis, RBS scores were positively correlated with MD in the same regions. These results would be predicted by the Macbeth effect, an obsession with dirt leading to hand-washing rituals resulting from guilt, made famous by the Shakespearian character Lady Macbeth. “What, will these hands ne’er be clean?” William Shakespeare (Shakespeare, 1606) Macbeth.

Item Type: Journal article
Publication Title: Scientific Reports
Creators: Nakagawa, S., Takeuchi, H., Taki, Y., Nouchi, R., Kotozaki, Y., Shinada, T., Maruyama, T., Sekiguchi, A., Iizuka, K., Yokoyama, R., Yamamoto, Y., Hanawa, S., Araki, T., Makoto Miyauchi, C., Magistro, D., Sakaki, K., Jeong, H., Sasaki, Y. and Kawashima, R.
Publisher: Nature Publishing Group
Date: 22 August 2019
Volume: 9
ISSN: 2045-2322
Identifiers:
NumberType
10.1038/s41598-019-48654-8DOI
48654Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 19 Sep 2019 15:16
Last Modified: 19 Sep 2019 15:16
URI: http://irep.ntu.ac.uk/id/eprint/37703

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