Mesenchymal stem cells, autoimmunity and rheumatoid arthritis

El-Jawhari, J., El-Sherbiny, Y.M. ORCID: 0000-0003-4791-3475, Jones, E. and McGonagle, D., 2014. Mesenchymal stem cells, autoimmunity and rheumatoid arthritis. QJM: An International Journal of Medicine, 107 (7), pp. 505-514. ISSN 1460-2725

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Abstract

The vast majority of literature pertaining to mesenchymal stem cells (MSC) immunomodulation has focussed on bone marrow-derived MSC that are systemically infused to alleviate inflammatory conditions. Rheumatoid arthritis (RA) is the commonest autoimmune joint disease that has witnessed significant therapeutic advances in the past decade, but remains stubbornly difficult to treat in a subset of cases. Pre-clinical research has demonstrated that bone marrow, adipose, synovial and umbilical cord-derived MSC all suppress the functions of different immune cells thus raising the possibility of new therapies for autoimmune diseases including RA. Indeed, preliminary evidence for MSC efficacy has been reported in some cases of RA and systemic lupus erythromatosis. The potential use of bone marrow-MSC (BM-MSC) for RA therapy is emerging but the use of synovial MSC (S-MSC) to suppress the exaggerated immune response within the inflamed joints remains rudimentary. Synovial fibroblasts that are likely derived from S-MSCs, also give rise to a cell-cultured progeny termed fibroblast-like synoviocytes (FLS), which are key players in the perpetuation of joint inflammation and destruction. A better understanding of the link between these cells and their biology could be a key to developing novel MSC-based strategies for therapy. The review briefly focuses on BM-MSC and gives particular attention to joint niche synovial MSC and FLS with respect to immunoregulatory potential therapy roles.

Item Type: Journal article
Publication Title: QJM: An International Journal of Medicine
Creators: El-Jawhari, J., El-Sherbiny, Y.M., Jones, E. and McGonagle, D.
Publisher: Oxford University Press
Date: July 2014
Volume: 107
Number: 7
ISSN: 1460-2725
Identifiers:
NumberType
10.1093/qjmed/hcu033DOI
1199913Other
Rights: © The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 14 Oct 2019 14:35
Last Modified: 14 Oct 2019 14:35
URI: http://irep.ntu.ac.uk/id/eprint/37953

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