Phase relationships in two-dimensional mass spectrometry

Van Agthoven, M.A., Kilgour, D.P.A. ORCID: 0000-0002-3860-7532, Lynch, A.M., Barrow, M.P., Morgan, T.E., Wootton, C.A., Chiron, L., Delsuc, M. and O’Connor, P.B., 2019. Phase relationships in two-dimensional mass spectrometry. Journal of The American Society for Mass Spectrometry. ISSN 1044-0305

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Abstract

Two-dimensional mass spectrometry (2D MS) is a data-independent tandem mass spectrometry technique in which precursor and fragment ion species can be correlated without the need for prior ion isolation. The behavior of phase in 2D Fourier transform mass spectrometry is investigated with respect to the calculation of phase-corrected absorption-mode 2D mass spectra. 2D MS datasets have a phase that is defined differently in each dimension. In both dimensions, the phase behavior of precursor and fragment ions is found to be different. The dependence of the phase for both precursor and fragment ion signals on various parameters (e.g., modulation frequency, shape of the fragmentation zone) is discussed. Experimental data confirms the theoretical calculations of the phase in each dimension. Understanding the phase relationships in a 2D mass spectrum is beneficial to the development of possible algorithms for phase correction, which may improve both the signal-to-noise ratio and the resolving power of peaks in 2D mass spectra.

Item Type: Journal article
Publication Title: Journal of The American Society for Mass Spectrometry
Creators: Van Agthoven, M.A., Kilgour, D.P.A., Lynch, A.M., Barrow, M.P., Morgan, T.E., Wootton, C.A., Chiron, L., Delsuc, M. and O’Connor, P.B.
Publisher: Springer
Date: 15 October 2019
ISSN: 1044-0305
Identifiers:
NumberType
10.1007/s13361-019-02308-1DOI
1202749Other
Rights: © The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 22 Oct 2019 10:12
Last Modified: 22 Oct 2019 10:12
URI: http://irep.ntu.ac.uk/id/eprint/38018

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