Are atrial fibrillation highest dominant frequency (HDF) areas the source of dominant excitation patterns? A left atrial panoramic view

Vanheusden, F. ORCID: 0000-0003-2369-6189, Ulusow, A., Chu, G.S., Li, X., Salinet, J.L., Stafford, P.J., Ng, G.A. and Schlindwein, F.S., 2019. Are atrial fibrillation highest dominant frequency (HDF) areas the source of dominant excitation patterns? A left atrial panoramic view. In: Computing in Cardiology (CinC 2019), Singapore, 8-11 September 2019.

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Abstract

Atrial fibrillation (AF) catheter ablation success depends on the possibility to accurately determine areas on the atrial endocardium at which AF activation originates. One way to determine if major AF activation pathways originate at identified source is through causality analysis. This work assessed to what extent left atrial highest dominant frequency (HDF) areas can be identified as sources of activation pathways in 10 male subjects suffering from persistent AF. Virtual electrograms were collected from 64 endocardial locations for at least 5 minutes. Frequency and causality were analyzed on 4 s signal segments Causality was assessed using the directed transfer function (DTF) algorithm, and AF activation sources were identified as endocardial locations of which the VEGM signal had high influence on other VEGM signals. Co-localization of high influence and HDF areas was evaluated for different area overlap and spectral organisation (OI) thresholds. Results show that, on average, good overlap only existed in 64.6% (± 8.8%) over all subject using the lowest threshold settings. Good overlap rates reduced with more conservative thresholds. This indicates that HDF areas might not always identify origins of main AF activation pathways.

Item Type: Conference contribution
Creators: Vanheusden, F., Ulusow, A., Chu, G.S., Li, X., Salinet, J.L., Stafford, P.J., Ng, G.A. and Schlindwein, F.S.
Date: September 2019
Identifiers:
NumberType
1206745Other
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 25 Oct 2019 09:22
Last Modified: 25 Oct 2019 09:22
URI: http://irep.ntu.ac.uk/id/eprint/38041

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