Antigen array for serological diagnosis and novel allergen identification in severe equine asthma

White, S.J. ORCID: 0000-0002-3675-7545, Moore-Colyer, M., Marti, E., Hannant, D., Gerber, V., Coüetil, L., Richard, E.A. and Alcocer, M., 2019. Antigen array for serological diagnosis and novel allergen identification in severe equine asthma. Scientific Reports, 9: 15170. ISSN 2045-2322

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Abstract

Severe equine asthma (sEA), which closely resembles human asthma, is a debilitating and performance-limiting allergic respiratory disorder which affects 14% of horses in the Northern Hemisphere and is associated with increased allergen-specific immunoglobulin E (IgE) against a range of environmental proteins. A comprehensive microarray platform was developed to enable the simultaneous detection of allergen-specific equine IgE in serum against a wide range of putative allergenic proteins. The microarray revealed a plethora of novel pollen, bacteria, mould and arthropod proteins significant in the aetiology of sEA. Moreover, the analyses revealed an association between sEA-affected horses and IgE antibodies specific for proteins derived from latex, which has traditionally been ubiquitous to the horse’s environment in the form of riding surfaces and race tracks. Further work is required to establish the involvement of latex proteins in sEA as a potential risk factor. This work demonstrates a novel and rapid approach to sEA diagnosis, providing a platform for tailored management and the development of allergen-specific immunotherapy.

Item Type: Journal article
Publication Title: Scientific Reports
Creators: White, S.J., Moore-Colyer, M., Marti, E., Hannant, D., Gerber, V., Coüetil, L., Richard, E.A. and Alcocer, M.
Publisher: Nature Publishing Group
Date: 23 October 2019
Volume: 9
ISSN: 2045-2322
Identifiers:
NumberType
10.1038/s41598-019-51820-7DOI
1207697Other
Divisions: Schools > School of Animal, Rural and Environmental Sciences
Record created by: Jonathan Gallacher
Date Added: 30 Oct 2019 13:27
Last Modified: 30 Oct 2019 13:27
URI: http://irep.ntu.ac.uk/id/eprint/38081

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