Design and testing of microbubble‐based MRI contrast agents for gastric pressure measurement

Abdurakman, E., Bencsik, M. ORCID: 0000-0002-6278-0378, Cave, G.W.V. ORCID: 0000-0002-4167-1332, Hoad, C.L., McGowan, S., Fairhurst, D.J. ORCID: 0000-0001-5311-0762, Major, G., Gowland, P.A. and Bowtell, R., 2020. Design and testing of microbubble‐based MRI contrast agents for gastric pressure measurement. Magnetic Resonance in Medicine, 83 (3), pp. 1096-1108. ISSN 0740-3194

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Abstract

Purpose: This work demonstrates specifically tailored microbubble‐based preparations and their suitability as MRI contrast agents for ingestion and measuring temporal and spatial pressure variation in the human stomach.

Methods: Enhanced alginate spheres were prepared by incorporating gas‐filled microbubbles into sodium alginate solution followed by the polymerization of the mixture in an aqueous calcium lactate solution. The microbubbles were prepared with a phospholipid shell and perfluorocarbon gas filling, using a mechanical cavitational agitation regime. The NMR signal changes to externally applied pressure and coming from the enhanced alginate spheres were acquired and compared with that of alginate spheres without microbubbles. In vivo investigations were also carried out on healthy volunteers to measure the pressure variation in the stomach.

Results: The MR signal changes in the contrast agent exhibits a linear sensitivity of approximately 40% per bar, as opposed to no measurable signal change seen in the control gas‐free spheres. This novel contrast agent also demonstrates an excellent stability in simulated gastric conditions, including at body temperature. In vivo studies showed that the signal change exhibited in the meal within the antrum region is between 5% and 10%, but appears to come from both pressure changes and partial volume artifacts.

Conclusion: This study demonstrates that alginate spheres with microbubbles can be used as an MRI contrast agent to measure pressure changes. The peristaltic movement within the stomach is seen to substantially alter the overall signal intensity of the contrast agent meal. Future work must focus on improving the contrast agent's sensitivity to pressure changes.

Item Type: Journal article
Publication Title: Magnetic Resonance in Medicine
Creators: Abdurakman, E., Bencsik, M., Cave, G.W.V., Hoad, C.L., McGowan, S., Fairhurst, D.J., Major, G., Gowland, P.A. and Bowtell, R.
Publisher: John Wiley & Sons
Date: March 2020
Volume: 83
Number: 3
ISSN: 0740-3194
Identifiers:
NumberType
10.1002/mrm.27992DOI
1268755Other
Rights: © 2019 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 10 Jan 2020 14:23
Last Modified: 10 Jan 2020 14:23
URI: http://irep.ntu.ac.uk/id/eprint/38951

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