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Turner, M.D. 
ORCID: 0000-0001-7175-1053, Gonzalez, L.L. and Garrie, K.,
2020.
Role of S100 proteins in health and disease.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research: 118677.
ISSN 0167-4889
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Abstract
The S100 family of proteins contains 25 known members that share a high degree of sequence and structural similarity. However, only a limited number of family members have been characterized in depth, and the roles of other members are likely undervalued. Their importance should not be underestimated however, as S100 family members function to regulate a diverse array of cellular processes including proliferation, differentiation, inflammation, migration and/or invasion, apoptosis, Ca2+ homeostasis, and energy metabolism. Here we detail S100 target protein interactions that underpin the mechanistic basis to their function, and discuss potential intervention strategies targeting S100 proteins in both preclinical and clinical situations.
| Item Type: | Journal article | ||||||||
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| Publication Title: | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | ||||||||
| Creators: | Turner, M.D., Gonzalez, L.L. and Garrie, K. | ||||||||
| Publisher: | Elsevier | ||||||||
| Date: | 11 February 2020 | ||||||||
| ISSN: | 0167-4889 | ||||||||
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| Divisions: | Schools > School of Science and Technology | ||||||||
| Record created by: | Jonathan Gallacher | ||||||||
| Date Added: | 18 Feb 2020 15:41 | ||||||||
| Last Modified: | 31 May 2021 15:06 | ||||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/39233 |
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