Role of S100 proteins in health and disease

Turner, M.D. ORCID: 0000-0001-7175-1053, Gonzalez, L.L. and Garrie, K., 2020. Role of S100 proteins in health and disease. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research: 118677. ISSN 0167-4889

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Abstract

The S100 family of proteins contains 25 known members that share a high degree of sequence and structural similarity. However, only a limited number of family members have been characterized in depth, and the roles of other members are likely undervalued. Their importance should not be underestimated however, as S100 family members function to regulate a diverse array of cellular processes including proliferation, differentiation, inflammation, migration and/or invasion, apoptosis, Ca2+ homeostasis, and energy metabolism. Here we detail S100 target protein interactions that underpin the mechanistic basis to their function, and discuss potential intervention strategies targeting S100 proteins in both preclinical and clinical situations.

Item Type: Journal article
Publication Title: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Creators: Turner, M.D., Gonzalez, L.L. and Garrie, K.
Publisher: Elsevier
Date: 11 February 2020
ISSN: 0167-4889
Identifiers:
NumberType
10.1016/j.bbamcr.2020.118677DOI
S0167488920300355Publisher Item Identifier
1292971Other
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 18 Feb 2020 15:41
Last Modified: 30 Sep 2020 10:41
URI: http://irep.ntu.ac.uk/id/eprint/39233

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