AGAP2: modulating TGFβ1-signalling in the regulation of liver fibrosis

Navarro‐Corcuera, A., Ansorena, E., Montiel-Duarte, C. ORCID: 0000-0002-9144-8809 and Iraburu, M.J., 2020. AGAP2: modulating TGFβ1-signalling in the regulation of liver fibrosis. International Journal of Molecular Sciences, 21 (4): 1400. ISSN 1661-6596

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Abstract

AGAP2 (Arf GAP with GTP-binding protein-like domain, Ankyrin repeat and PH domain 2) isoform 2 is a protein that belongs to the Arf GAP (GTPase activating protein) protein family. These proteins act as GTPase switches for Arfs, which are Ras superfamily members, being therefore involved in signaling regulation. Arf GAP proteins have been shown to participate in several cellular functions including membrane trafficking and actin cytoskeleton remodeling. AGAP2 is a multi-tasking Arf GAP that also presents GTPase activity and is involved in several signaling pathways related with apoptosis, cell survival, migration, and receptor trafficking. The increase of AGAP2 levels is associated with pathologies as cancer and fibrosis. Transforming growth factor beta-1 (TGF-β1) is the most potent pro-fibrotic cytokine identified to date, currently accepted as the principal mediator of the fibrotic response in liver, lung, and kidney. Recent literature has described that the expression of AGAP2 modulates some of the pro-fibrotic effects described for TGF-β1 in the liver. The present review is focused on the interrelated molecular effects between AGAP2 and TGFβ1 expression, presenting AGAP2 as a new player in the signaling of this pro-fibrotic cytokine, thereby contributing to the progression of hepatic fibrosis.

Item Type: Journal article
Publication Title: International Journal of Molecular Sciences
Creators: Navarro‐Corcuera, A., Ansorena, E., Montiel-Duarte, C. and Iraburu, M.J.
Publisher: MDPI
Date: 19 February 2020
Volume: 21
Number: 4
ISSN: 1661-6596
Identifiers:
NumberType
10.3390/ijms21041400DOI
1293399Other
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 19 Feb 2020 14:06
Last Modified: 19 Feb 2020 14:06
URI: http://irep.ntu.ac.uk/id/eprint/39234

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