Development of hepatic pathology in GBV‐B‐infected red‐bellied tamarins (Saguinus labiatus)

Dale, J.M., Hood, S.P., Bowen, O., Bright, H., Cutler, K.L., Berry, N., Almond, N., Goldin, R., Karayiannis, P. and Rose, N.J., 2020. Development of hepatic pathology in GBV‐B‐infected red‐bellied tamarins (Saguinus labiatus). Journal of Medical Virology. ISSN 0146-6615

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Abstract

GB virus B (GBV‐B) is a new world monkey‐associated flavivirus used to model acute hepatitis C virus (HCV) infection. Critical for evaluation of antiviral or vaccine approaches is an understanding of the effect of HCV on the liver at different stages of infection. In the absence of longitudinal human tissue samples at defined time points, we have characterized changes in tamarins. As early as 2 weeks post‐infection histological changes were noticeable, and these were established in all animals by 6 weeks. Despite high levels of liver‐associated viral RNA, there was reversal of hepatic damage on clearance of peripheral virus though fibrosis was demonstrated in four tamarins. Notably, viral RNA burden in the liver dropped to near undetectable or background levels in all animals which underwent a second viral challenge, highlighting the efficacy of the immune response in removing foci of replication in the liver. These data add to the knowledge of GBV‐B infection in New World primates which can offer attractive systems for the testing of prophylactic and therapeutic treatments and the evaluation of their utility in preventing or reversing liver pathology.

Item Type: Journal article
Publication Title: Journal of Medical Virology
Creators: Dale, J.M., Hood, S.P., Bowen, O., Bright, H., Cutler, K.L., Berry, N., Almond, N., Goldin, R., Karayiannis, P. and Rose, N.J.
Publisher: Wiley
Date: 17 March 2020
ISSN: 0146-6615
Identifiers:
NumberType
10.1002/jmv.25769DOI
1312752Other
Rights: © 2020 Crown copyright. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 03 Apr 2020 07:55
Last Modified: 22 May 2020 14:48
URI: http://irep.ntu.ac.uk/id/eprint/39543

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