Inflammatory signaling and brown fat activity

Omran, F. and Christian, M. ORCID: 0000-0002-1616-4179, 2020. Inflammatory signaling and brown fat activity. Frontiers in Endocrinology, 11: 156. ISSN 1664-2392

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Abstract

Obesity is characterized by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory cytokines. In comparison to WAT, relatively little is known about the inflammatory status of brown adipose tissue (BAT) in physiology and pathophysiology. Because BAT and brown/beige adipocytes are specialized in energy expenditure they have protective roles against obesity and associated metabolic diseases. BAT appears to be is less susceptible to developing inflammation than WAT. However, there is increasing evidence that inflammation directly alters the thermogenic activity of brown fat by impairing its capacity for energy expenditure and glucose uptake. The inflammatory microenvironment can be affected by cytokines secreted by immune cells as well as by the brown adipocytes themselves. Therefore, pro-inflammatory signals represent an important component of the thermogenic potential of brown and beige adipocytes and may contribute their dysfunction in obesity.

Item Type: Journal article
Publication Title: Frontiers in Endocrinology
Creators: Omran, F. and Christian, M.
Publisher: Frontiers Research Foundation
Date: 2020
Volume: 11
ISSN: 1664-2392
Identifiers:
NumberType
10.3389/fendo.2020.00156DOI
1324610Other
Rights: © 2020 Omran and Christian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 12 May 2020 10:22
Last Modified: 22 Jun 2020 09:31
URI: http://irep.ntu.ac.uk/id/eprint/39816

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