Targeted genptype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes

Crossland, H., Piasecki, J. ORCID: 0000-0001-9758-6295, Mccormick, D., Phillips, B.E., Wilkinson, D., Smith, K., Mcphee, J.S., Piasecki, M. and Atherton, P.J., 2020. Targeted genptype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes. AJP - Regulatory, Integrative and Comparative Physiology. ISSN 0363-6119

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Abstract

Recent large genome-wide association studies (GWAS) have independently identified a set of genetic loci associated with lean body mass (LBM) and handgrip strength (HGS). Evaluation of these candidate single nucleotide polymorphisms (SNPs) may be useful to investigate genetic traits of populations at higher or lower risk of muscle dysfunction. As such, we investigated associations between six SNPs linked to LBM or HGS, in a population of elite master athletes (MA), and age-matched controls, as a representative population of older individuals with variable maintenance of muscle mass and function. Genomic DNA was isolated from buffy coat samples of 96 individuals (consisting of 48 MA (71±6yrs; age graded performance 83±9%) and 48 older controls (75±6yrs)). SNP validation and sample genotyping was conducted using the tetra-primer amplification refractory mutation system (ARMS). For the 3 SNPs analysed that were previously associated with LBM (FTO, IRS1 and ADAMTSL3), multinomial logistic regression revealed a significant association of the ADAMTSL3 genotype with %LBM (P

Item Type: Journal article
Alternative Title: Elite master athlete genotype [running head]
Publication Title: AJP - Regulatory, Integrative and Comparative Physiology
Creators: Crossland, H., Piasecki, J., Mccormick, D., Phillips, B.E., Wilkinson, D., Smith, K., Mcphee, J.S., Piasecki, M. and Atherton, P.J.
Publisher: American Physiological Society
Date: 24 June 2020
ISSN: 0363-6119
Identifiers:
NumberType
10.1152/ajpregu.00110.2020DOI
1341464Other
32579386PubMed ID
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 07 Jul 2020 08:31
Last Modified: 07 Jul 2020 08:31
URI: http://irep.ntu.ac.uk/id/eprint/40179

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