Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

Vikulina, A., Voronin, D., Fakhrullin, R., Vinokurov, V. and Volodkin, D. ORCID: 0000-0001-7474-5329, 2020. Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose. New Journal of Chemistry, 44 (15), pp. 5638-5655. ISSN 1144-0546

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Abstract

Recent advances in drug delivery and controlled release had a great impact on bioscience, medicine and tissue engineering. Consequently, a variety of advanced drug delivery vehicles either have already reached the market or are approaching the phase of commercial production. Progressive growth of the drug delivery market has led to the necessity to earnestly concern about economically viable, up-scalable and sustainable technologies for a large-scale production of drug delivery carriers. We have identified three attractive natural sources of drug carriers: aluminosilicate clays, minerals of calcium carbonate, and cellulose. Three classes of drug delivery carriers derived from these natural materials are halloysite nanotubes, vaterite crystals and nanocellulose. These carriers can be produced using “green” technologies from some of the most abundant sources on the Earth and have extremely high potential to meet all criteria applied for the manufacture of modern delivery carriers. We provide an up-to-date snapshot of these drug delivery vehicles towards their use for bioapplications, in particular for drug delivery and tissue engineering. The following research topics are addressed: (i) the availability, sources and methodologies used for production of these drug delivery vehicles, (ii) the drug loading and release mechanisms of these delivery vehicles, (iii) in vitro, in vivo, and clinical studies on these vehicles, and (iv) employment of these vehicles for tissue engineering. Finally, the prospects for vehicles’ further development and industrialisation are critically assessed, highlighting most attractive future research directions such as the design of third generation active biomaterials.

Item Type: Journal article
Publication Title: New Journal of Chemistry
Creators: Vikulina, A., Voronin, D., Fakhrullin, R., Vinokurov, V. and Volodkin, D.
Publisher: Royal Society of Chemistry
Date: 21 April 2020
Volume: 44
Number: 15
ISSN: 1144-0546
Identifiers:
NumberType
10.1039/c9nj06470bDOI
1347109Other
Rights: ©The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2020. Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Divisions: Schools > School of Science and Technology
Record created by: Jill Tomkinson
Date Added: 29 Jul 2020 13:44
Last Modified: 29 Jul 2020 13:44
URI: http://irep.ntu.ac.uk/id/eprint/40293

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