Tools
Tools
Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Hanawa, S., Araki, T., Miyauchi, C.M., Sakaki, K., Nozawa, T., Ikeda, S., Yokota, S., Magistro, D. 
ORCID: 0000-0002-2554-3701, Sassa, Y. and Kawashima, R.,
2020.
Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms.
Scientific Reports, 10: 12364.
ISSN 2045-2322
|
Text
1347481_Magistro.pdf - Published version Download (1MB) | Preview |
Abstract
Zinc is a biologically essential element and involved in a wide range of cellular processes. Here, we investigated the associations of zinc levels in hair with brain activity during the n-back working memory task using functional magnetic resonance imaging, fractional anisotropy (FA) of diffusion tensor imaging, and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that greater hair zinc levels were associated with lower brain activity during working memory in extensive areas in the default mode network (i.e., greater task-induced deactivation) as well as greater FA in white matter areas near the hippocampus and posterior limbs of the internal capsule. These findings advance previous non-neuroimaging findings of zinc’s associations with excitability, excitability-associated disorders, and myelination.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Scientific Reports | ||||||
| Creators: | Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Hanawa, S., Araki, T., Miyauchi, C.M., Sakaki, K., Nozawa, T., Ikeda, S., Yokota, S., Magistro, D., Sassa, Y. and Kawashima, R. | ||||||
| Publisher: | Springer Science and Business Media LLC | ||||||
| Date: | 23 July 2020 | ||||||
| Volume: | 10 | ||||||
| ISSN: | 2045-2322 | ||||||
| Identifiers: |
|
||||||
| Rights: | © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jill Tomkinson | ||||||
| Date Added: | 03 Aug 2020 15:21 | ||||||
| Last Modified: | 31 May 2021 15:18 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/40306 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
