Pharmaceutical and environmental analysis using membrane inlet mass spectrometry

Gomez Lamarca, D., 2002. Pharmaceutical and environmental analysis using membrane inlet mass spectrometry. PhD, Nottingham Trent University.

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Abstract

The development of membrane inlet mass spectrometry strategies for semivolatile and volatile organic compounds has been investigated. Linear quadrapole and ion trap mass spectrometers have been used for detection of tar get analytes related to the pharmaceutical industry. In-membrane pre-concentration membrane inlet mass spectrometry has been employed for the analysis of semi-volatile organic compounds in aqueous samples. A drying stage between in-membrane pre-concentration and thermal desorption has been incorporated into the technique, increasing sensitivity. Matrix and pH studies have also been carried out to optimise the effects caused to MIMS analysis. The in-membrane pre-concentration procedure has been applied to biodegradation monitoring. The technique compared well with HPLC and ion chromatography methods for the at-line monitoring of 4-FBA and 4-FCA biodegradation process. An on-line monitoring system was also developed and validated. The technique has been demonstrated for the biodegradation of a mixture of nitrogen compounds relevant to the pharmaceutical industry. Reversed-phase membrane inlet mass spectrometry incorporating a hollow fibre Nafion® membrane has been developed for the determination of methanol and ethanol in chloroform. The hydrophilic Nafion® membrane preferentially transports methanol and ethanol, whilst discriminating against a chloroform. The system has been evaluated for the monitoring of a chloroform recovery process using a residual gas analyser and the data compared to an established GC/MS analyser. A temperature controlled membrane inlet has been constructed as a universal interface for hollow-fibre silicone membranes. The membrane temperature is controlled by an electrical heater and sub-ambient temperatures were obtained using a flow of cooled nitrogen gas. The device has been linked to mass spectrometry and GC/MS for the determination of volatile and semi-volatile organic compounds in aqueous and air samples at temperatures in the range -70-250°C.

Item Type: Thesis
Creators: Gomez Lamarca, D.
Date: 2002
ISBN: 9781369312676
Identifiers:
NumberType
PQ10182969Other
Divisions: Schools > School of Science and Technology
Record created by: Jill Tomkinson
Date Added: 25 Aug 2020 10:15
Last Modified: 26 Aug 2020 11:55
URI: http://irep.ntu.ac.uk/id/eprint/40506

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