Electrospinning/electrospraying coatings for metal microneedles: a design of experiments (DOE) and quality by design (QbD) approach

Ali, R., Mehta, P., Kyriaki Monou, P., Arshad, M.S., Panteris, E., Rasekh, M., Singh, N., Qutachi, O., Wilson, P. ORCID: 0000-0003-0207-2246, Tzetzis, D., Chang, M.-W., Fatouros, D.G. and Ahmad, Z., 2020. Electrospinning/electrospraying coatings for metal microneedles: a design of experiments (DOE) and quality by design (QbD) approach. European Journal of Pharmaceutics and Biopharmaceutics, 156, pp. 20-39. ISSN 0939-6411

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Abstract

The research presented here shows QbD implementation for the optimisation of the key process parameters in electrohydrodynamic atomisation (EHDA). Here, the electrosprayed nanoparticles and electrospun fibers consisting of a polymeric matrix and dye. Eight formulations were assessed consisting of 5% w/v of polycaprolactone (PCL) in dichloromethane (DCM) and 5% w/v polyvinylpyrrolidone (PVP) in ethanol. A full factorial DOE was used to assess the various parameters (applied voltage, deposition distance, flow rate). Further particle and fiber analysis using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Fourier Transform Infrared Spectroscopy (FTIR), particle/fiber size distribution. In addition to this in vitro release studied were carried out using fluorescein and Rhodamine B as model dyes and in vitro permeation studies were applied. The results show a significant difference in the morphology of resultant structures as well as a more rapid release profile for the PVP particles and fibers in comparison to the sustained release profiles found with PCL. In vitro drug release studies showed 100% drug release after 7 days for PCL particles and showed 100% drug release within 120 min for PVP particles. The release kinetics and the permeation study showed that the MN successfully pierced the membrane and the electrospun MN coating released a large amount of the loaded drug within 6 h. This study has demonstrated the capability of these robust MNs to encapsulate a diverse range drugs within a polymeric matrix giving rise to the potential of developed personalised medical devices.

Item Type: Journal article
Publication Title: European Journal of Pharmaceutics and Biopharmaceutics
Creators: Ali, R., Mehta, P., Kyriaki Monou, P., Arshad, M.S., Panteris, E., Rasekh, M., Singh, N., Qutachi, O., Wilson, P., Tzetzis, D., Chang, M.-W., Fatouros, D.G. and Ahmad, Z.
Publisher: Elsevier
Date: November 2020
Volume: 156
ISSN: 0939-6411
Identifiers:
NumberType
10.1016/j.ejpb.2020.08.023DOI
S0939641120302678Publisher Item Identifier
1362494Other
Divisions: Schools > School of Animal, Rural and Environmental Sciences
Record created by: Linda Sullivan
Date Added: 09 Sep 2020 09:37
Last Modified: 10 Nov 2020 11:03
URI: http://irep.ntu.ac.uk/id/eprint/40644

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