Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with a focus on advanced fabrication techniques

Askarieh, M., Afzali Naniz, M., Kouhi, M., Saberi, A., Zolfagharian, A. and Bodaghi, M. ORCID: 0000-0002-0707-944X, 2020. Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with a focus on advanced fabrication techniques. Biomaterials Science. ISSN 2047-4830

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Abstract

Over the last decade, 3D bioprinting has received immense attention from research communities for developing functional tissues. Thanks to the complexity of tissues, various bioprinting methods are exploited to figure out the challenges of tissue fabrication, in which hydrogels are widely adopted as a bioink in cell printing technologies based on the extrusion principle. Thus far, there is a wealth of the literature proposing the crucial parameters of extrusion-based bioprinting of hydrogel biomaterials (e.g., hydrogel properties, printing conditions, and tissue scaffold design) toward enhancing performance. Despite the growing research in this field, numerous challenges that hinder advanced applications still exist. Herein, the most recently reported hydrogel-based bioprinted scaffolds, i.e., skin, bone, cartilage, vascular, neural, and muscular (including skeletal, cardiac, and smooth), are systematically discussed with an emphasis on the advanced fabrication techniques from tissue engineering perspective. Methods covered include the multiple-dispenser, coaxial, and hybrid 3D bioprinting. The present work is a unique study to figure out the opportunities of the novel techniques to fabricate complicated constructs with structural and functional heterogeneity. Finally, the principal challenges of current studies and a vision of future research are presented.

Item Type: Journal article
Publication Title: Biomaterials Science
Creators: Askarieh, M., Afzali Naniz, M., Kouhi, M., Saberi, A., Zolfagharian, A. and Bodaghi, M.
Publisher: Royal Society of Chemistry (RSC)
Date: 9 October 2020
ISSN: 2047-4830
Identifiers:
NumberType
10.1039/d0bm00973cDOI
1376234Other
Rights: © The Royal Society of Chemistry. Open Access Article. Published on 09 October 2020. Downloaded on 10/11/2020 9:30:22 AM. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 13 Oct 2020 13:35
Last Modified: 13 Oct 2020 13:35
URI: http://irep.ntu.ac.uk/id/eprint/41281

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