The association of the ACTN3 R577X and ACE I/D polymorphisms with athlete status in football: a systematic review and meta-analysis

McAuley, A.B.T., Hughes, D.C., Tsaprouni, L.G., Varley, I. ORCID: 0000-0002-3607-8921, Suraci, B., Roos, T.R., Herbert, A.J. and Kelly, A.L., 2020. The association of the ACTN3 R577X and ACE I/D polymorphisms with athlete status in football: a systematic review and meta-analysis. Journal of Sports Sciences. ISSN 0264-0414

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Abstract

The aim of this review was to assess the association of ACTN3 R577X and ACE I/D polymorphisms with athlete status in football and determine which allele and/or genotypes are most likely to influence this phenotype via a meta-analysis. A comprehensive search identified 17 ACTN3 and 19 ACE studies. Significant associations were shown between the presence of the ACTN3 R allele and professional footballer status (OR = 1.35, 95% CI: 1.18–1.53) and the ACE D allele and youth footballers (OR = 1.18, 95% CI: 1.01–1.38). More specifically, the ACTN3 RR genotype (OR = 1.48, 95% CI: 1.23–1.77) and ACE DD genotype (OR = 1.29, 95% CI: 1.02–1.63) exhibited the strongest associations, respectively. These findings may be explained by the association of the ACTN3 RR genotype and ACE DD genotype with power-orientated phenotypes and the relative contribution of power-orientated phenotypes to success in football. As such, the results of this review provide further evidence that individual genetic variation may contribute towards athlete status and can differentiate athletes of different competitive playing statuses in a homogenous team-sport cohort. Moreover, the ACTN3 R577X and ACE I/D polymorphisms are likely (albeit relatively minor) contributing factors that influence athlete status in football.

Item Type: Journal article
Publication Title: Journal of Sports Sciences
Creators: McAuley, A.B.T., Hughes, D.C., Tsaprouni, L.G., Varley, I., Suraci, B., Roos, T.R., Herbert, A.J. and Kelly, A.L.
Publisher: Taylor & Francis
Date: 28 August 2020
ISSN: 0264-0414
Identifiers:
NumberType
10.1080/02640414.2020.1812195DOI
1364587Other
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 18 Nov 2020 09:17
Last Modified: 18 Nov 2020 09:17
URI: http://irep.ntu.ac.uk/id/eprint/41657

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