Alzheimer's disease and Type 2 diabetes: a critical assessment of the shared pathological traits

Chatterjee, S. ORCID: 0000-0002-2506-1278 and Mudher, A., 2018. Alzheimer's disease and Type 2 diabetes: a critical assessment of the shared pathological traits. Frontiers in Neuroscience, 12: 383. ISSN 1662-4548

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Abstract

Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most prevalent diseases in the elderly population worldwide. A growing body of epidemiological studies suggest that people with T2DM are at a higher risk of developing AD. Likewise, AD brains are less capable of glucose uptake from the surroundings resembling a condition of brain insulin resistance. Pathologically AD is characterized by extracellular plaques of Aβ and intracellular neurofibrillary tangles of hyperphosphorylated tau. T2DM, on the other hand is a metabolic disorder characterized by hyperglycemia and insulin resistance. In this review we have discussed how Insulin resistance in T2DM directly exacerbates Aβ and tau pathologies and elucidated the pathophysiological traits of synaptic dysfunction, inflammation, and autophagic impairments that are common to both diseases and indirectly impact Aβ and tau functions in the neurons. Elucidation of the underlying pathways that connect these two diseases will be immensely valuable for designing novel drug targets for Alzheimer's disease.

Item Type: Journal article
Publication Title: Frontiers in Neuroscience
Creators: Chatterjee, S. and Mudher, A.
Publisher: Frontiers Media SA
Date: 8 June 2018
Volume: 12
ISSN: 1662-4548
Identifiers:
NumberType
10.3389/fnins.2018.00383DOI
1394805Other
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 16 Dec 2020 09:59
Last Modified: 16 Dec 2020 09:59
URI: http://irep.ntu.ac.uk/id/eprint/41879

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