Horizontal gene transfer as a source of conflict and cooperation in prokaryotes

Hall, R.J., Whelan, F.J., McInerney, J.O., Ou, Y. and Domingo-Sananes, M.R. ORCID: 0000-0002-3339-8671, 2020. Horizontal gene transfer as a source of conflict and cooperation in prokaryotes. Frontiers in Microbiology, 11: 1569.

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Abstract

Horizontal gene transfer (HGT) is one of the most important processes in prokaryote evolution. The sharing of DNA can spread neutral or beneficial genes, as well as genetic parasites across populations and communities, creating a large proportion of the variability acted on by natural selection. Here, we highlight the role of HGT in enhancing the opportunities for conflict and cooperation within and between prokaryote genomes. We discuss how horizontally acquired genes can cooperate or conflict both with each other and with a recipient genome, resulting in signature patterns of gene co-occurrence, avoidance, and dependence. We then describe how interactions involving horizontally transferred genes may influence cooperation and conflict at higher levels (populations, communities, and symbioses). Finally, we consider the benefits and drawbacks of HGT for prokaryotes and its fundamental role in understanding conflict and cooperation from the gene-gene to the microbiome level.

Item Type: Journal article
Publication Title: Frontiers in Microbiology
Creators: Hall, R.J., Whelan, F.J., McInerney, J.O., Ou, Y. and Domingo-Sananes, M.R.
Publisher: Frontiers Media
Date: 17 July 2020
Volume: 11
Identifiers:
NumberType
10.3389/fmicb.2020.01569DOI
1403959Other
Rights: © 2020 Hall, Whelan, McInerney, Ou and Domingo-Sananes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 29 Jan 2021 15:04
Last Modified: 29 Jan 2021 15:04
URI: http://irep.ntu.ac.uk/id/eprint/42147

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