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Lawingco, T., Chaudhury, S., Brookes, K.J. 
ORCID: 0000-0003-2427-2513, Guetta-Baranes, T., Guerreiro, R., Bras, J., Hardy, J., Francis, P., Thomas, A., Belbin, O. and Morgan, K.,
2020.
Genetic variants in glutamate, Aβ and tau related pathways determine polygenic risk for Alzheimer's disease.
Neurobiology of Aging.
ISSN 0197-4580
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1389839_Brookes.pdf - Post-print Download (481kB) | Preview |
Abstract
Synapse loss is an early event in late-onset Alzheimer's disease (LOAD). In this study we have assessed the capacity of a polygenic risk score (PRS) restricted to synapse-encoding loci to predict LOAD. We used summary statistics from the IGAP genome-wide association meta-analysis of 74,046 subjects for model construction and tested the "Synaptic PRS" in two independent datasets of controls and pathologically-confirmed LOAD. The mean Synaptic PRS was 2.3-fold higher in LOAD compared to controls (p
| Item Type: | Journal article | ||||||||
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| Publication Title: | Neurobiology of Aging | ||||||||
| Creators: | Lawingco, T., Chaudhury, S., Brookes, K.J., Guetta-Baranes, T., Guerreiro, R., Bras, J., Hardy, J., Francis, P., Thomas, A., Belbin, O. and Morgan, K. | ||||||||
| Publisher: | Elsevier | ||||||||
| Date: | 12 November 2020 | ||||||||
| ISSN: | 0197-4580 | ||||||||
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| Divisions: | Schools > School of Science and Technology | ||||||||
| Record created by: | Linda Sullivan | ||||||||
| Date Added: | 01 Feb 2021 09:37 | ||||||||
| Last Modified: | 31 May 2021 15:07 | ||||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/42152 |
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