Genetic variants in glutamate, Aβ and tau related pathways determine polygenic risk for Alzheimer's disease

Lawingco, T., Chaudhury, S., Brookes, K.J. ORCID: 0000-0003-2427-2513, Guetta-Baranes, T., Guerreiro, R., Bras, J., Hardy, J., Francis, P., Thomas, A., Belbin, O. and Morgan, K., 2020. Genetic variants in glutamate, Aβ and tau related pathways determine polygenic risk for Alzheimer's disease. Neurobiology of Aging. ISSN 0197-4580

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Abstract

Synapse loss is an early event in late-onset Alzheimer's disease (LOAD). In this study we have assessed the capacity of a polygenic risk score (PRS) restricted to synapse-encoding loci to predict LOAD. We used summary statistics from the IGAP genome-wide association meta-analysis of 74,046 subjects for model construction and tested the "Synaptic PRS" in two independent datasets of controls and pathologically-confirmed LOAD. The mean Synaptic PRS was 2.3-fold higher in LOAD compared to controls (p

Item Type: Journal article
Publication Title: Neurobiology of Aging
Creators: Lawingco, T., Chaudhury, S., Brookes, K.J., Guetta-Baranes, T., Guerreiro, R., Bras, J., Hardy, J., Francis, P., Thomas, A., Belbin, O. and Morgan, K.
Publisher: Elsevier
Date: 12 November 2020
ISSN: 0197-4580
Identifiers:
NumberType
10.1016/j.neurobiolaging.2020.11.009DOI
S0197458020303912Publisher Item Identifier
1389839Other
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 01 Feb 2021 09:37
Last Modified: 01 Feb 2021 09:37
URI: http://irep.ntu.ac.uk/id/eprint/42152

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